CAS: 105-57-7; Acetal

上下游产品

CAS号64-17-5 乙醇 | CAS号75-07-0 乙醛 | CAS号79865-08-0 2-chloro-2,3-di... | CAS号109-92-2 乙烯基乙醚 | CAS号54509-73-8 ethene | CAS号201230-82-2 carbon monoxide | CAS号501-65-5 二苯乙炔 | CAS号7440-21-3 硅 | CAS号74-86-2 乙炔 | CAS号67-56-1 甲醇 | CAS号105443-02-5 4-[1-[4-(diethy... | CAS号534-15-6 乙缩醛二甲醇 | CAS号22251-34-9 methoxymethoxyethane | CAS号462-95-3 二乙氧基甲烷 | CAS号10471-14-4 1-乙氧基-1-甲氧基乙烷 | CAS号64-17-5 乙醇 | CAS号108009-54-7 trimethylsilyl ... | CAS号33419-42-0 依托泊苷 | CAS号110-81-6 二乙基二硫 | CAS号3600-24-6 二乙基三硫醚

乙醇置于四丁基氯化铵体系中,化学反应生成乙缩醛
参考文献:通过电化学生成的次氯酸乙酯中间体选择性氯化物介导的纯乙醇氧化为 1,1-二乙氧基乙烷
标题:通过电化学生成的次氯酸乙酯中间体选择性氯化物介导的纯乙醇氧化为 1,1-二乙氧基乙烷
摘要:选择性伯醇氧化形成醛类产品而不过度氧化成羧酸仍然是一个关键的化学挑战.使用简单的烷基氯化铵作为电解质,在纯乙醇溶剂中使用玻璃碳工作电极,以 > 95% 的法拉第效率 (Fe) 制备 1,1-二乙氧基乙烷 (Dee).Dee 用作保护乙醛免受过度氧化和挥发的储存平台.紫外-可见分光光度法显示反应通过次氯酸乙酯中间体作为唯一的氯化物氧化产物进行,并且该中间体以单分子方式分解(速率常数k = (6.896 +/-0.516) x 10-4 S-1) 形成 Hcl 催化剂和乙醛,乙醛经乙醇溶剂快速亲核攻击,形成 Dee 产物.由于氯阴离子氧化的快速动力学,这种间接氧化机制能够在低得多的正电位下进行乙醇氧化.
Doi:10.1021/jacs.1C05976

专利信息

专利号:US-9884885-B2
优先权日:2009-05-18
标题:Synthesis of labile base protected-modified deoxy and modified ribo nucleosides, corresponding phosphoramidites and supports and their use in high purity oligonucleotide synthesis
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P; CHEMGENES CORP
摘要:This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base, nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using N-acetyl protected guanine as nucleoside base protecting group, which is significantly faster base labile protecting group, yet significantly more stable than commonly utilized-2-isobutyryl guanosine is a novel approach to obtain highest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups, including acetyl group from guanine and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of acetyl protecting groups of the natural deoxy and ribonucleosides occurs under substantially reduced time in contact with mild deprotection conditions such as mild bases, secondary amines for removal of such groups under such conditions would allows synthesis of various DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is designed to lead to high purity large scale therapeutic grade oligonucleotide chimeras which consist of fluoro sugar modification in conjunction with deoxy nucleosides, ribonucleosides, modified base and modified sugar nucleosides. This approach is further designed to use acetyl guanine protecting group when other bases are sensitive nucleoside, and for use in oligo peptide synthesis and for support bound oligo nucleotides.

专利号:US-7652164-B2
优先权日:2005-09-13
标题:Process for the direct synthesis of trialkoxysilane
发明人：LEWIS KENRICK M; MEREIGH ABELLARD T; O'YOUNG CHI-LIN; CAMERON RUDOLPH A
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:The Direct Synthesis of trialkoxysilane is carried out by conducting the Direct Synthesis reaction of silicon and alcohol, optionally in solvent, in the presence of a catalytically effective amount of Direct Synthesis catalyst and an effective catalyst-promoting amount of Direct Synthesis catalyst promoter, said promoter being an organic or inorganic compound possessing at least one phosphorus-oxygen bond.

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

专利号:US-3992413-A
优先权日:1975-07-25
标 题 :Intermediates in the synthesis of prostaglandins
发明人：TAUB DAVID; WENDLER NORMAN L
权利人:MERCK & CO INC
摘要:The invention relates to a new and novel synthesis of prostaglandin E 2 , and it particularly relates to a novel process starting with relatively inexpensive starting materials. The invention further relates to a synthesis which is readily adaptable for large scale processing because of the high yields in the individual reaction steps. n The invention further relates to novel compounds formed as intermediates in the synthesis of prostaglandin E 2 . The invention still further relates to synthetic analogs and known metabolites of prostaglandin E 2 and prostaglandin E 1 , useful as standards in certain biological assays for determining prostaglandin-like activity.

专利号:US-2010099894-A1
优先权日:2006-10-09
标 题 :Method for the Synthesis of Cyclic Acetals by the Reactive Extraction of a Polyol in a Concentrated Solution
发明人：DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO
权利人:DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO
摘要:A method for the synthesis of cyclic acetals comprises reacting at least one carbonyl-function compound selected from aldehydes, ketones, and/or linear acetals, on a polyol in a concentrated aqueous solution exceeding 20 wt % in a reactor containing an acidic catalyst. The carbonyl-function compound is selected so that the cyclic acetal obtained has a water solubility lower than 20000 mg/kg. During the catalytic reaction for the cyclic acetal synthesis, at least one portion of the organic phase containing the cyclic acetal is separated. The acidic catalysis is either homogeneous when using a water-soluble strong acid, or heterogeneous when using a solid acid such as a resin, a zeolite, or any appropriately acidified solid. The extractive reaction method can be used for obtaining high conversions and selectivity.