CAS: 100-27-6; 4-Nitrophenethyl Alcohol

相似化合物

69628-98-4 104-03-0 104-10-9

上下游产品

CAS号104-03-0 对硝基苯乙酸 | CAS号5445-26-1 对硝基苯乙酸乙酯 | CAS号6388-74-5 2-(4-硝基苯基)环氧乙烷 | CAS号104-10-9 2-(4-氨基苯基)乙醇 | CAS号19910-33-9 α-甲基-4-硝基苯乙酸 | CAS号99-81-0 2-溴-4'-硝基苯乙酮 | CAS号100-19-6 对硝基苯乙酮 | CAS号104-30-3 Benzeneethanol,... | CAS号100-13-0 4-硝基苯乙烯 | CAS号19922-82-8 2-Bromo-1-(4-ni... | CAS号104-30-3 Benzeneethanol,... | CAS号5339-26-4 4-硝基苯乙基溴 | CAS号4836-69-5 2,4-二硝基苯乙醇 | CAS号50438-75-0 2-(4-(二甲基氨基)苯基)乙醇 | CAS号19935-81-0 1-(1-溴乙基)-4-硝基苯 | CAS号210158-20-6 4-(2-(4-硝基苯基)乙基)吗啉 | CAS号19935-75-2 1-(1-chloroethy... | CAS号20264-95-3 1-氯-2-(4-硝基苯基)乙烷 | CAS号20264-96-4 1-(2-碘乙基)-4-硝基苯 | CAS号100-19-6 对硝基苯乙酮

4-硝基苯乙烯置于1,3-二甲基脲,三(N,N-四亚甲基)磷酰胺,碳酸氢钠,间氯过氧苯甲酸,Lithium Chloride体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 8.0H,反应生成对硝基苯乙醇
参考文献:环氧化物电还原
标题:环氧化物电还原
摘要:环氧化物的选择性加氢将是一种直接且有效的醇合成方法,但已被证明是难以捉摸的.在这里,报道了使用电子和质子作为还原剂的电化学环氧化物加氢.在没有过渡金属的情况下,可以通过选择性马尔科夫尼科夫或反马尔科夫尼科夫开环来获得范围广泛的伯醇,仲醇和叔醇.机理研究表明,区域选择性受芳基取代环氧化物原位生成苄基自由基的热力学稳定性和烷基取代环氧化物马尔科夫尼科夫选择性开环的动力学趋势控制.
Doi:10.1021/jacs.1C11791

专利信息

专利号:WO-9323413-A1
优先权日:1992-05-13
标 题:Synthesis of nucleotide monomers
发明人：BEIGELMAN LEONID; MATULIC-ACADEMIC JASENKA
权利人:RIBOZYME PHARM INC
摘要:Methods for synthesis of 2',3'-dideoxycytidine, 2',3'-dideoxyguanosine, 2',3'-dideoxyadenosine, 2',3'-dideoxyinosine and 2',3'-dideoxyguanosine, and 3'-O-benzoyl-2'-deoxyribonucleoside.

专利号:US-6872535-B2
优先权日:1998-05-20
标题:Three-dimensional array of supports for solid-phase parallel synthesis and method of use
发明人：BAUM STEPHEN A
权利人:AVENTIS PHARMA INC
摘要:A three-dimensional (3D) array of solid-phase supports is adapted to provide parallel synthesis of a library of molecules with 3D diversity. Individual locations in the 3D array may be assigned to selected molecules in the library such that molecules may be synthesized at and retrieved from such locations. Also, the supports include aperture walls in stacked plates; the supports may be suspended within stacked plate apertures; the 3D array include discrete supports arranged in columns in one or more wells; the supports include tube inner walls or be suspended in tubes, the tubes being secured in stacked, two-dimensional (2D) frameworks; or the supports include beads contained in porous enclosures having non-porous side walls and being secured in stacked, 2D frameworks. A support transfer device enables transfer of solid-phase supports used in a 3D array. Such apparatus includes: a rack of rods sized to be inserted through supports and a mechanism to prevent supports from coming off the rack; tubes connected to a vacuum manifold to suction supports one Z plane at a time; or a transfer block having recesses to receive one or more support and at least one gate withholding supports from passing through the gate when in a closed position. A method of 3D synthesis includes: a) functionalizing solid-phase supports; b) placing supports in a 3D array; and c) performing parallel synthesis with 3D diversity. At least one unique R 1 group member may be assigned to each Z plane.

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:WO-2022220019-A1
优先权日:2021-04-16
标题 :Long-chain dna synthesis using non-natural base
发明人：MASAKI YOSHIAKI
权利人:TOKYO INST TECH
摘要:The purpose of the present invention is to provide a method for synthesizing a long-chain nucleic acid (particularly DNA) with high accuracy. The present invention provides a method for synthesizing a long-chain nucleic acid, the method comprising using: (i) a nucleoside-3'-O-phosphoramidite derivative having a non-natural nucleic acid base; or (ii) a nucleoside-3'-O-phosphoramidite derivative having a non-natural nucleic acid base and a nucleoside-3'-O-phosphoramidite derivative having a natural nucleic acid base in the chemical synthesis of a nucleic acid based on the phosphoramidite method.

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.