CAS: 85803-43-6; S-Benzyl-L-Cysteinol

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CAS号22728-88-7 S-benzyl-(L)-cy... | CAS号52844-67-4 S-苄基-L-半胱氨酸乙酯盐酸盐 | CAS号953-18-4 ethyl 2-amino-3... | CAS号3054-01-1 S-苄基-L-半胱氨酸 | CAS号139428-96-9 N-叔丁氧羰基-S-苄基-L-半胱氨醇

📜S-苄基-L-半胱氨酸乙酯盐酸盐置于锂硼氢体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 S-苄基-L-半胱胺醇
参考文献:Pyrimidinylpropenamides As Antitumor Agents. Analogs Of The Antibiotic Sparsomycin
标题:Pyrimidinylpropenamides As Antitumor Agents. Analogs Of The Antibiotic Sparsomycin
摘要:A Series Of Pyrimidinylpropenamides 9 And Their Oxidation Products 10 Was Prepared,As Analogues Of Sparsomycin (1),For Antitumor Evaluation. Syntheses Involved Condensation Of The Appropriate Amino Alcohol 5 With Acid 8. The Resulting Sulfides 9 Were Then Oxidized With Naio4 Or H2O2 To Sulfoxides 10. Activity Was Studied In Lymphocytic Leukemia P-338 And Kb Cell Culture. With The Exception Of The N-Decyl Analogue,All Of The Deoxygenated Compounds 9 Were Inactive Regardless Of The Stereochemical Form. In The Sulfoxide Series 10,Those Compounds Prepared With An L Configuration At The Asymmetric Carbon Were Also Inactive. The Completely Racemic Sulfoxides,On The Other Hand,Displayed Substantial Antitumor Activity (Ils = 37-61% In P-388; Ed50 = 1.2-2.4 Mug/ml In Kb) Suggesting That Both The Presence Of A Sulfoxide Moiety And A D Configuration At The Chiral Carbon Atom Were Structural Requirements For A Positive Antitumor Response. There Appeared To Be A Large Tolerance For The Group Substituted At The Sulfoxide Moiety,However.
DOI:10.1021/jm00213A004

专利信息

专利号:US-10328141-B2
优先权日:2013-07-07
标题:Synthetic vaccines against Streptococcus pneumoniae type 1
发明人：SEEBERGER PETER H; PEREIRA CLANEY LEBEV; ANISH CHAKKUMKAL; SCHUMANN BENJAMIN
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to the total synthesis of saccharide structures contained in the capsular polysaccharide of Streptococcus pneumoniae type 1, to glycoconjugates containing said saccharide structures obtained by total synthesis and to use of such glycoconjugates and pharmaceutical compositions thereof in the immunization against diseases associated with bacteria containing said saccharide structures in their capsular polysaccharide, and more specifically associated with Streptococcus pneumoniae.

专利号:US-6660832-B1
优先权日:1999-08-20
标题:Macrocyclic compounds and preparation methods thereof
发明人：JEFFERSON ELIZABETH; SWAYZE ERIC EDWARD
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention is directed to macrocyclic compounds of the formula (I)wherein Q, X, R1 and R5 are as defined herein. Compounds of the invention are useful for therapeutic and prophylactic treatment of bacterial infection in mammals. Solid phase synthetic procedures are provided effecting synthesis of the macrocyclic rings attached to a solid support.

专利号:CN-105492454-B
优先权日:2013-07-07
标 题:Synthesis is directed to the vaccine of 1 type streptococcus pneumonia