CAS: 82209-74-3; 3-(2-((1R,4As,5R,8As)-5-(Hydroxymethyl)-5,8A-Dimethyl-2-Methylenedecahydronaphthalen-1-yl)Ethyl)Furan-2(5H)-One
该化合物是具有独特结构特征的复杂有机化合物,含有一个由五人组成的内酯环,代之以包括多个立体分点的氯化萘衍生物,表明其性能;水氧甲基和二甲基组的存在有助于其潜在的再活性和溶性;该化合物由于其结构复杂性,可能展示出有趣的生物活动,使其在医药化学和天然产品合成等领域具有兴趣;其分子结构表明其在红味和口味工业以及药物开发中的潜在应用;然而,诸如熔点,沸点和溶性等具体特性需要实证数据,以便精确地定性.
- 英文名称3-(2-((1R,4As,5R,8As)-5-(Hydroxymethyl)-5,8A-Dimethyl-2-Methylenedecahydronaphthalen-1-yl)Ethyl)Furan-2(5H)-One
- 中文名称新穿心莲内酯苷元
- IUPAC名称3-(2-((1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
- 其它别名3-[2-[(1R,4As,5R,8As)-Decahydro-5-(Hydroxymethyl)-5,8A-Dimethyl-2-Methylene-1-Naphthalenyl]Ethyl]-2(5H)-Furanone, Ent-19-Hydroxy-8(17),13-Labdadien-16,15-Olide; 3,14-Dideoxyandrographolide; 3-[2-[(1R,4As,5R,8As)-Decahydro-5-(Hydroxymethyl)-5,8A-Dimethyl
- CAS编号82209-74-3
- MFCD编号:MFCD07778568
- FDA UNII编号:89M92UDM18
- 分子式:C20H30O3分子量:318.46
- 产品CID: 1813524
- 产品分类分析化学 → 标准品 → 分析标准品
物理性质
MSDS等安全信息
上下游产品
neoandrographolide neoandrographolide合成工艺路线路线简述
- 合成目标产物 19-Hydroxy-8(17),13-Labdadien-16,15-Olide 主要起始原料 Neoandrographolide
- (文献来源)合成步骤主要原料 Neoandrographolide
📜新穿心莲内酯置于takadiastase体系中,用 水 作为反应溶剂,化学反应 118.0H,以37 Mg的收率获得产物新穿心莲内酯苷元
参考文献:Fujita,Tetsuro; Fujitani,Ryujiro; Takeda,Yoshio,Chemical And Pharmaceutical Bulletin,1984,Vol. 32,# 6,P. 2117-2125
标题:Fujita,Tetsuro; Fujitani,Ryujiro; Takeda,Yoshio,Chemical And Pharmaceutical Bulletin,1984,Vol. 32,# 6,P. 2117-2125
海关参考信息
- 2901210000-乙烯
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2905121000-正丙醇
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专利信息
专利号:CN-119662575-A
优先权日:2024-12-19
标题 :A hydroxylase and its application in the synthesis of 14-deoxyandrographolide
专利号:US-2021290651-A1
优先权日:2020-03-20
标 题:Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
专利号:US-2021308117-A1
优先权日:2020-03-20
标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
专利号:US-2021315880-A1
优先权日:2020-03-20
标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
专利号:WO-2021189018-A9
优先权日:2020-03-20
标 题 :Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
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主要参考文献
1: Yin B, Umar T, Ma X, Chen Y, Umar Z, Umer S, Deng G. Andrograpanin mitigates lipopolysaccharides induced endometritis via TLR4/NF-κB pathway. Reprod Biol. 2022 Mar;22(1):100606. doi: 10.1016/j.repbio.2022.100606. Epub 2022 Jan 20. 8(7):951-8. doi: 10.1016/j.intimp.2007.12.014. Epub 2008 Jan 17. 95(5):970-8. doi: 10.1002/jcb.20464. 36(10):143. doi: 10.1007/s11274-020-02919-x. 68(1):96-99. doi: 10.1248/cpb.c19-00662. 43(11):2300-2312. Chinese. doi: 10.19540/j.cnki.cjcmm.20180408.006. 194(4):1716-1739. doi: 10.1007/s12010-021-03778-4. Epub 2022 Jan 8. 297(3):101045. doi: 10.1016/j.jbc.2021.101045. Epub 2021 Aug 4.
9: Majumdar M, Singh V, Misra TK, Roy DN. In silico studies on structural inhibition of SARS-CoV-2 main protease Mpro by major secondary metabolites of Andrographis paniculata and Cinchona officinalis. Biologia (Bratisl). 2022;77(5):1373-1389. doi: 10.1007/s11756-022-01012-y. Epub 2022 Feb 28.
10: Deiva Suga SS, Krishna Mohan S, Sreekandan RN, K M, Kamaraj D, Veeraraghavan VP, Jayaraman S, Rajagopal P. Molecular docking analysis of phytocompounds from Andrographis paniculata binding with proteins in the notch-signaling pathway. Bioinformation. 2020 Nov 30;16(11):923-928. doi: 10.6026/97320630016923.
合成参考文献
参考文献:10.1021/np0704452
摘要:Chen L, Zhu H, Wang R, Zhou K, Jing Y, Qiu F. ent-Labdane Diterpenoid Lactone Stereoisomers from Andrographis paniculata. J. Nat. Prod. 2008 Mar 22;71(5):852–5. doi: 10.1021/np0704452.
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