CAS: 78092-65-6; 2-(Pyridin-4-Ylmethylsulfanyl)Ethanol

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CAS号75-21-8 环氧乙烷 | CAS号107-07-3 2-氯乙醇 | CAS号540-51-2 2-溴乙醇

📜4-溴甲基吡啶,2-巯基乙醇置于caesium Carbonate体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 10.0H,以20%的收率获得产物利司硫醇
参考文献:Thiazolidinone Compounds And Use Thereof
标题:Thiazolidinone Compounds And Use Thereof
摘要:一种含有化合物(i)的药物组合物,用于治疗与阿片受体相关的疾病.还公开了一种使用这种化合物治疗阿片受体相关疾病的方法.进一步公开了两组式(i)的噻唑烷酮化合物:(i)每种化合物的对映体过量大于90%;(II)每种化合物被氘取代.

专利信息

专利号:US-4500535-A
优先权日:1979-10-15
标 题:Method of regulating the immune response with pyridine derivatives
发明人：LOMBARDINO JOSEPH G; HARBERT CHARLES A
权利人:PFIZER
摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)-pyridine [alternatively named 2-(4-picolylthio)acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.

专利号:US-4371696-A
优先权日:1980-07-14
标 题 :Certain pyridine methylthio acetaldehyde derivatives and non-cyclic and cyclic acetals thereof
发明人：LOMBARDINO JOSEPH G; HARBERT CHARLES A
权利人:PFIZER
摘要:A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having antiinflammatory and immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C 1 -C 4 )alkyl esters thereof, and 4-(1-formylmethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)-acetaldehyde] and bis(C 1 -C 4 )alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.