CAS: 77377-52-7; N-(Tert-Butyldimethylsilyl)-2,2,2-Trifluoro-N-Methylacetamide

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CAS号815-06-5 N-甲基三氟乙酰胺 | CAS号18162-48-6 叔丁基二甲基氯硅烷 | CAS号18052-27-2 tert-butyl-dime...

📜N-甲基-2,2,2-三氟乙酰胺,叔丁基二甲基氯硅烷置于sodium Hydride体系中,化学反应生成 N-(特丁基二甲基硅)-N-甲基三氟乙酰胺
参考文献:N-Methyl-N-(Tert-Butyldimethylsilyl)Trifluoroacetamide And Related N-Tert-Butyldimethylsilyl Amides As Protective Silyl Donors
标题:N-Methyl-N-(Tert-Butyldimethylsilyl)Trifluoroacetamide And Related N-Tert-Butyldimethylsilyl Amides As Protective Silyl Donors
摘要:
DOI:10.1021/jo00138A032

专利信息

专利号:US-9422259-B2
优先权日:2011-01-18
标题:Synthetic transtaganolide and basiliolide products, derivatives thereof, and synthesis methods thereof
发明人：NELSON HOSEA; MURAKAMI KEI; VIRGIL SCOTT C; STOLTZ BRIAN M; GORDON JONATHAN R
权利人:CALIFORNIA INST OF TECHN
摘要:Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.

专利号:US-9169502-B2
优先权日:2010-06-15
标题 :Method of producing L-lysine using a Corynebacterium glutamicum microorganism
发明人：WITTMANN CHRISTOPH; BECKER JUDITH
权利人:WITTMANN CHRISTOPH; BECKER JUDITH; PAIK KWANG IND CO LTD
摘要:The present invention is directed to a method utilizing a recombinant microorganism for the production of aspartate derived amino acids and precursors thereof, in particular for the production of L-lysine. Furthermore, the present invention relates to a recombinant microorganism having improved aspartate-derived amino acid synthesis activity in comparison to the initial microorganism and the use of such microorganisms in producing said amino acids and precursors and derivatives, in particular in the synthesis of L-lysine.

专利号:US-8759632-B2
优先权日:2005-07-05
标 题 :Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof
发明人：RO DAE-KYUN; NEWMAN KARYN; PARADISE ERIC M; KEASLING JAY D; OUELLET MARIO; EACHUS RACHEL; HO KIMBERLY; HAM TIMOTHY
权利人:RO DAE-KYUN; NEWMAN KARYN; PARADISE ERIC M; KEASLING JAY D; OUELLET MARIO; EACHUS RACHEL; HO KIMBERLY; HAM TIMOTHY; UNIV CALIFORNIA
摘要:The present invention provides isolated nucleic acids comprising nucleotide sequences encoding isoprenoid modifying enzymes, as well as recombinant vectors comprising the nucleic acids. The present invention further provides genetically modified host cells comprising a subject nucleic acid or recombinant vector. The present invention further provides a transgenic plant comprising a subject nucleic acid. The present invention further provides methods of producing an isoprenoid compound, the method generally involving culturing a subject genetically modified host cell under conditions that permit synthesis of an isoprenoid compound modifying enzyme encoded by a subject nucleic acid.

专利号:WO-2025104679-A1
优先权日:2023-11-16
标题 :Processes for making intermediates for isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity
发明人：SHAKYA SAGAR; JOHNSON MATT; WONG NICHOLAS; BODHURI PRABHUDAS; DAVAR NIPUN
权利人:OTSUKA PHARMA CO LTD
摘要:The present disclosure relates to processes for preparing synthetic intermediates for the synthesis of isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity.

专利号:US-2013288320-A1
优先权日:2012-04-27
标题 :Methods and microorganisms for increasing the biological synthesis of difunctional alkanes
发明人：LAU MAN KIT
权利人:BIOAMBER INC
摘要:A method of increasing the production a difunctional alkane in a microorganism that produces a difunctional alkane from alpha-keto acid by increasing the production of homocitrate in the cell relative to a wild-type or parent cell. The production of homocitrate may be obtained by engineering pathways that increase the production of alpha-ketoacid, such as alpha-ketoglutarate.

专利号:US-9605019-B2
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids
发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.