CAS: 7703-74-4; 2,6-Bis(Bromomethyl)Pyridine

相似化合物

68470-59-7 31106-82-8 73004-40-7

上下游产品

CAS号1195-59-1 2,6-吡啶二甲醇 | CAS号108-48-5 2,6-二甲基吡啶 | CAS号499-83-2 2,6-吡啶二羧酸 | CAS号15658-60-3 2,6-吡啶二羧酸二乙酯 | CAS号591-51-5 苯基锂 | CAS号5453-67-8 2,6-吡啶二甲酸二甲酯 | CAS号122637-39-2 6-乙酰基-2-吡啶羧酸 | CAS号5431-44-7 2,6-吡啶二甲醛 | CAS号20746-55-8 1,4,7,10,13,16(... | CAS号25117-68-4 3,11-Dithia-17,... | CAS号58048-08-1 3,11,19-trithia... | CAS号73892-45-2 2,6-双[(二苯基膦基)甲基]吡啶 | CAS号66433-94-1 2,6-bis(phenoxy... | CAS号66433-95-2 2-[[6-[(2-formy... | CAS号86309-74-2 3,6,9,12,15,18,... | CAS号78668-34-5 3,6,9,15-tetraz...

📜2,6-二甲基吡啶置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈体系中,用 苯 作为反应溶剂,化学反应 1.5H,以22%的收率获得产物2,6-双(溴甲基)吡啶
参考文献:Thielocin B1类似物作为pac3同型二聚体的蛋白-蛋白相互作用抑制剂的合成和生物学评估
标题:Thielocin B1类似物作为pac3同型二聚体的蛋白-蛋白相互作用抑制剂的合成和生物学评估
摘要:Thielocin B1类似物的合成和生物学评估已得到证实.通过简单的酯化或醚化反应简明地合成了在中心核和末端羧酸部分中修饰的十四个类似物.对作为蛋白酶体组装伴侣(pac)复合物(pac3同型二聚体和pac1 / Pac2)抑制剂的合成类似物的评估表明,类似天然产物的弯曲结构和末端羧酸基团对其生物学活性至关重要.此外,Sar和计算机对接研究表明,Thielocin B1的二苯醚部分上的所有甲基均通过疏水作用对pac3同型二聚体产生有效和选择性的抑制作用.
DOI:10.1016/j.Bmc.2018.11.001

专利信息

专利号:WO-9000622-A1
优先权日:1988-07-08
标题 :Oligonucleotide hybridization probes and means for the synthesis of the most preferred probes
发明人：KWIATKOWSKI MAREK; SUND CHRISTIAN; HURSKAINEN PERTTI
权利人:WALLAC OY; PHARMACIA AB
摘要:Oligonucleotide probe labeled at one of its teminal positions with a non-linear branched polymer carrying a plurality of negatively charged groups, preferably phosphodiester groups, and optionally also analytically indicatable groups covalently linked to terminal ends of the branches of said polymer. The preferred indicatable groups are lanthanide chelates. A compound that can be used for the synthesis of the probe is also disclosed. The compound has formula (I), where R1 and R2 are lower alkyl; R3 is lower alkyl (C1-C7), or aryl each of which optionally being provided with electron-withdrawing substituents; and A1, A2 and A3 are hydrogen, A'-O-B, A''-O-B or A'''-O-B, at most one of A1-3 being hydrogen and A', A'' and A''' being a hydrocarbon chain providing a distance of 5-9 atoms between the phosphorous atom and the oxygen directly bound to B, and B being a protecting group. In the preferred compound at least two of A1-3 are identical while the other is hydrogen.

专利号:WO-9964032-A1
优先权日:1998-06-08
标题 :Combinatorial synthesis of multibinding libraries
发明人：CHRISTENSEN BURTON G; GRIFFIN JOHN H; JENKINS THOMAS E; JUDICE J KEVIN
权利人:ADVANCED MEDICINE INC; CHRISTENSEN BURTON G; GRIFFIN JOHN H; JENKINS THOMAS E; JUDICE J KEVIN
摘要:Disclosed are methods for synthesizing large collections of diverse multimeric compounds as well as iterative processes for evaluating key molecular constraints imparting multibinding properties to multimeric compounds. Also disclosed are libraries of multimeric compounds which can be evaluated for imparting multibinding properties.

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人：SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

专利号:US-7071290-B2
优先权日:2001-03-13
标题 :Polymers and oligomers, their synthesis, and electronic devices incorporating same
发明人：EPSTEIN ARTHUR J; WANG DAIKE
权利人:UNIV OHIO STATE
摘要:The invention relates to polymers and oligomers, methods of their synthesis, and electronic devices comprising them.

专利号:US-2008193357-A1
优先权日:2005-07-29
标 题:Method for Enantioselective Synthesis of Phosphorus-Stereogenic Phosphines

专利号:FR-2964106-A1
优先权日:2010-08-27
标 题:NEW CATALYSTS FOR THE SYNTHESIS OF POLYURETHANES