五氟苯置于四丁基硫酸氢铵 Sodium Hydroxide体系中,用 环己烷 作为反应溶剂,以68%的收率获得产物2,3,5,6-四氟苯酚 参考文献:Nucleophilic Aromatic Substitution By Hydroxide Ion Under Phase-Transfer Catalysis Conditions; Fluorine Displacement In Polyfluorobenzene Derivatives 标题:Nucleophilic Aromatic Substitution By Hydroxide Ion Under Phase-Transfer Catalysis Conditions; Fluorine Displacement In Polyfluorobenzene Derivatives 摘要: DOI:10.1021/jo00026A033
专利号:US-12421534-B2 优先权日:2021-11-10 标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs 发明人:ALMHJELL PATRICK J; ARNOLD FRANCES H 权利人:CALIFORNIA INST OF TECHN 摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.
专利号:US-2024076303-A1 优先权日:2022-09-07 标 题:Green Synthesis of Salicylaldehydate-Metal-Organic Frameworks and Applications Thereof 发明人:SHETTY DINESH; MOHAMMED ABDUL KHAYUM 权利人:UNIV KHALIFA SCIENCE & TECHNOLOGY 摘要:Embodiments of the present disclosure generally describe two-dimensional/three-dimensional conjugated salicylaldehydate metal organic framework (2D/3D-c-SA MOF) compositions, method for green synthesis of the two-dimensional/three-dimensional conjugated salicylaldehydate metal organic framework (2D/3D-c-SA MOF) compositions, applications of the said compositions in supercapacitors, lithium-ion batteries, electrocatalytic conversion reactions, photocatalytic reduction of CO 2 and other uses.
专利号:US-2024294464-A1 优先权日:2021-10-27 标题 :Synthesis of restrained complexing agents 发明人:WONG NICHOLAS; GOSSELIN FRANCIS 权利人:GENENTECH INC 摘要:Improved methods of synthesis of a restrained complexing agent are described herein. Compounds, including salts and solvates thereof, and compositions relevant to the improved methods are also described.
专利号:US-9802890-B2 优先权日:2006-02-21 标 题 :Processes for the convergent synthesis of calicheamicin derivatives 发明人:MORAN JUSTIN KEITH; GU JIANXIN 权利人:WYETH LLC 摘要:This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
专利号:WO-2018047197-A1 优先权日:2016-09-07 标 题 :Site-selective peptides and protein labelling and synthesis of homogenous protein conjugates 发明人:RAI VISHAL; CHILAMARI MAHESHWERREDDY; PURUSHOTTAM LANDA 权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES BHOPAL 摘要:The invention pertains to the method for the site selective modification of peptides and proteins comprising of the activation of the single site (N É› -NH 2 ) of peptides and proteins and the method comprising one of formylation; interception of formylation; alkynylation or amino phosphonation of peptides and proteins.
专利号:WO-2025149479-A1 优先权日:2024-01-12 标题:Synthesis of modified nucleoside triphosphates 发明人:KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL 权利人:ROCHE DIAGNOSTICS GMBH 摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.
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合成参考文献
摘要:Lloyd, C. M.; Dowell, K. F.; Brittain, W. D. G., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2. 参考文献:10.1007/s00259-008-0816-z 摘要:Eder M, Wängler B, Knackmuss S, LeGall F, Little M, Haberkorn U, Mier W, Eisenhut M. Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for 68Ga-labeled small recombinant antibodies. European Journal of Nuclear Medicine and Molecular Imaging. 2008 May 29;35(10):1878–86. doi: 10.1007/s00259-008-0816-z.