专利号:US-4818816-A 优先权日:1981-04-28 标 题:Process for the organic synthesis of oligosaccharides and derivatives thereof 发明人:PETITOU MAURICE; JACQUINET JEAN-CLAUDE; SINAY PIERRE; CHOAY JEAN; LORMEAU JEAN-CLAUDE; NASSR MAHMOUD 权利人:CHOAY SA 摘要:The invention relates to a process for the organic synthesis of oligosaccharides constituting or comprising fragments of acid mucopolysaccharides comprising the reaction of two compounds constituted or terminated by units of glucosamine structure and of uronic acid structure respectively, said units being specifically substituted. This process particularly enables valuable anticoagulant drugs to be obtained.
专利号:WO-2004101476-A1 优先权日:2003-05-16 标题:Metathesis reaction involving the unsaturated side chain of an alpha, alpha-disubstituted amino acid 发明人:RUTJES FLORIS PETRUS JOHANNES; STORCKEN ROY PETRUS MARIA; BROXTERMAN QUIRINUS BERNARDUS; KAPTEIN BERNARDUS 权利人:DSM IP ASSETS BV; RUTJES FLORIS PETRUS JOHANNES; STORCKEN ROY PETRUS MARIA; BROXTERMAN QUIRINUS BERNARDUS; KAPTEIN BERNARDUS 摘要:The invention relates to a process for amino acid synthesis, i.e., the preparation of side chain unsaturated α,α-disubstituted-α-amino acid derivatives with formula (1) wherein: * denotes a stereogenic C-atom PG represents an N-protecting group or the C-terminal part of an optionally protected amino acid or peptide chain; X represents an optionally substituted amine group or an alkoxy group; R1 represents an optionally substituted alkyl group; Ri represents R2 or R3; if Ri = R2 then Rii = R5 and if Ri = R3 then Rii = H; R2, R3 and R5 each independently represent H, an optionally substituted (cyclo)alkyl, (hetero)aryl, acyl, alkoxycarbonyl, cyano, di-alkylphosphonyl, oxiranyl group, a CHO group optionally protected as its acetal, or a group derived from an O-protected carbohydrate, or R2 and R5 may form together with the C-atorn to which they are attached an optionally substituted hydrocarbon ring, with the proviso that R2 , R3 and R5 do not all represent H at the same time. R4 represents H, an alkyl group or an aryl group; n represents an integer larger than or equal to 0, via a cross metathesis reaction between the corresponding amino acid derivative precursor and an (eventually substituted) alkene.
专利号:US-2009298139-A1 优先权日:2006-02-28 标 题 :Method for Polymer Synthesis Using Microfluidic Enzymatic Cascade 发明人:ZOU JIN; KAPLAN DAVID L; ZOU JIN; WONG PETER Y; KAPLAN DAVID L 权利人:ZOU JIN; KAPLAN DAVID L; ZOU JIN; WONG PETER Y; KAPLAN DAVID L 摘要:The present invention discloses a method for producing polymers in a microscale device. The system utilizes a symmetrically branched system of microchannels interconnecting a plurality of loading decks and re-action chambers. The fluid flow is manipulated by the placement of capillary check valves, mixing areas, and microcomb filters. The system provides for cascading enzymatic biosynthesis pathways wherein any variety of enzymes and reactants can be introduced into the system to produce a final product.
专利号:CN-104059113-A 优先权日:2013-03-19 标 题 :A Simple Synthesis Method of Glucotriose, the Core Fragment of Plant Immunity Activator