CAS: 58236-70-7; 5-Bromo-3-Chloropyridin-2(1H)-One

相似化合物

1381937-58-1 1393550-81-6 5437-33-2

上下游产品

CAS号13466-35-8 3-氯-2-羟基吡啶 | CAS号160599-70-2 2,5-二溴-3-氯吡啶

3-氯-2-羟基吡啶置于溴,Sodium Sulfite体系中,用 N-甲基乙酰胺,水 作为反应溶剂,化学反应生成 2-羟基-3-氯-5-溴吡啶
参考文献:3-Chloropyridines,And Their Use In Liquid-Crystal Mixtures
标题:3-Chloropyridines,And Their Use In Liquid-Crystal Mixtures
摘要:3-氯吡啶,其制备方法以及它们在液晶混合物中的应用.式(i)的3-氯吡啶:##str1## 其中符号具有以下含义:R.Sup.1和r.Sup.2,彼此独立,例如,为h或直链或支链烷基,A.Sup.1,A.Sup.2,A.Sup.3和a.Sup.4相同或不同,例如,为1,4-苯撑基,吡嗪-2,5-二基或反-1,4-环己撑基,M.Sup.1,M.Sup.2,M.Sup.3和m.Sup.4相同或不同,例如,为--O--或--Co--O--,R.Sup.3,R.Sup.4,R.Sup.6和r.Sup.7彼此独立,例如,为h或直链或支链烷基,M.Sup.5例如,为--O--Co--或单键,K,L,M,N,O,P,Q和r为零或一,但须满足k+m+p+r的总和小于4且大于零,可优选作为铁电液晶混合物中的组分.

专利信息

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).