CAS: 5633-20-5; 4-(Diethylamino)But-2-Yn-1-Yl 2-Cyclohexyl-2-Hydroxy-2-Phenylacetate

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CAS号1508-65-2 盐酸奥昔布宁 | CAS号10575-25-4 4-二乙氨基-2-丁炔-1-醇 | CAS号4335-77-7 2-环己基-2-羟基苯乙酸 | CAS号22396-77-6 乙酸4-(二乙氨基)-2-丁炔醇酯 | CAS号10399-13-0 2-环己基-2-羟基苯乙酸甲酯 | CAS号10575-25-4 4-二乙氨基-2-丁炔-1-醇 | CAS号4335-77-7 2-环己基-2-羟基苯乙酸

📜盐酸奥昔布宁 以 水 作为反应溶剂,化学反应 4.0H,反应生成 奥昔布宁
参考文献:Modified Release Formulations Containing Drug-Ion Exchange Resin Complexes
标题:Modified Release Formulations Containing Drug-Ion Exchange Resin Complexes
摘要:提供一种含有涂层药物-离子交换树脂复合物的水性悬浮液,包括由苯丙胺与药用可接受离子交换树脂复合成的核和未涂层的苯丙胺-离子交换树脂复合物.涂层的苯丙胺-离子交换树脂复合物与聚合物混合形成基质.描述了制备涂层复合物和液体悬浮液的方法.

专利信息

专利号:US-6825378-B2
优先权日:2003-03-28
标 题 :Process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid
发明人：KUMAR PRADEEP; FERNANDES RODNEY AGUSTINHO; GUPTA PRITI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides a process for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1). The present invention more particularly relates to a process using cyclohexylphenyl ketone for the synthesis of enantiomerically pure cyclohexylphenyl glycolic acid of formula (1).

专利号:US-2024082118-A1
优先权日:2021-05-19
标 题:Topical compositions and methods of preparing the same
发明人：ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
权利人:LANDA LABS 2012 LTD
摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.

专利号:WO-2017137955-A1
优先权日:2016-02-14
标题:Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol
发明人：THOMBARE PRAVIN SAHADEV
权利人:CELESTIS PHARMACEUTICALS PVT LTD
摘要:The present invention relates to novel chiral 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine (5) and racemic 3-(2-(allyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine () and its use in improved and industrially advantageous process for preparation of chiral and racemic form of 2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol. Further, present invention relates to preparation of the same.

专利号:US-6140529-A
优先权日:1998-10-22
标 题 :Synthesis of optically active cyclohexylphenylglycolate esters
发明人：BAKALE ROGER P; LOPEZ JORGE L; MCCONVILLE FRANCIS X; VANDENBOSSCHE CHARLES P; SENANAYAKE CHRIS HUGH
权利人:SEPRACOR INC
摘要:A process for the preparation of optically active cyclohexylphenylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.

专利号:US-10022366-B2
优先权日:2013-04-23
标 题:Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery
发明人：STINCHCOMB AUDRA L; GHOSH PRIYANKA
权利人:STINCHCOMB AUDRA L; GHOSH PRIYANKA; UNIV MARYLAND; UNIV KENTUCKY RES FOUND
摘要:Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.

专利号:US-10035796-B2
优先权日:2014-08-14
标题:Crystalline forms of a BACE inhibitor, compositions, and their use
发明人：KAZAKEVICH IRINA; TRZASKA SCOTT; FENG TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.