专利号:US-6955915-B2 优先权日:1989-06-07 标题 :Apparatus comprising polymers 发明人:FODOR STEPHEN P A; STRYER LUBERT; PIRRUNG MICHAEL C; READ J LEIGHTON; HOEPRICH PAUL D 权利人:AFFYMETRIX INC 摘要:A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
[参考文献]: Cohen, Et Al. Local And Systemic Control Of Phytophthora Infestans In Tomato With Dl-3-Aminobutanoic Acid. Phytopathology. Volume: 84. Issue: 1. Pages: 55-9. Journal [参考文献]: J Gamir, Et Al. Identification Of Indole-3-Carboxylic Acid As Mediator Of Priming Against Plectosphaerella Cucumerina. Plant Physiol Biochem. 2012 Dec:61:169-79. [参考文献]: Jolanta Floryszak-Wieczorek, Et Al. Nitric Oxide-Mediated Stress Imprint In Potato As An Effect Of Exposure To A Priming Agent. Mol Plant Microbe Interact. 2012 Nov;25(11):1469-77. [参考文献]: Juhan Kim, Et Al. Cloning And Characterization Of A Novel Beta-Transaminase From Mesorhizobium Sp. Strain Luk: A New Biocatalyst For The Synthesis Of Enantiomerically Pure Beta-Amino Acids. Appl Environ Microbiol. 2007 Mar;73(6):1772-82. [参考文献]: Lennart Eschen-Lippold, Et Al. Dl-Beta-Aminobutyric Acid-Induced Resistance Of Potato Against Phytophthora Infestans Requires Salicylic Acid But Not Oxylipins. Mol Plant Microbe Interact. 2010 May;23(5):585-92.
合成参考文献
摘要:Hwang BY, Ko SH, Park HY, Seo JH, Lee BS, Kim BG. Identification of ω-aminotransferase from Caulobacter crescentus and site-directed mutagenesis to broaden substrate specificity. J Microbiol Biotechnol. 2008 Jan;18(1):48–54. 参考文献:10.1128/jb.187.17.5910-5917.2005 摘要:Geueke B, Namoto K, Seebach D, Kohler HP. A novel beta-peptidyl aminopeptidase (BapA) from strain 3-2W4 cleaves peptide bonds of synthetic beta-tri- and beta-dipeptides. J Bacteriol. 2005 Sep;187(17):5910–7.