CAS: 521-40-4; (-)-α-Narcotoline
- 英文名称(-)-α-Narcotoline
- 中文名称[S-(R*,R*)]-6,7-二甲氧基-3-(5,6,7,8-四氢-4-羟基-6-甲基-1,3-二氧杂环戊并[4,5-g]异喹啉-5-基)苯酞
- 其它别名[S-(R*,R*)]-6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)phthalide; narcotoline; (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-hydroxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one; Desmethylnarcotine; (3S)-3-[(5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-dimethoxy-3H-2-benzofuran-1-one; (3S)-3-[(5R)-4-hydroxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-dimethoxy-3H-isobenzofuran-1-one
- CAS编号521-40-4
- EINECS号:208-313-6
- FDA UNII编号:M5V1K1QE3F
- 分子式:C21H21NO7分子量:399.4
- 产品CID: 1512464
- 产品分类有机原料 → 生物碱及其衍生物 → 邻苯二甲酸异喹啉类
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2906210000-苄醇
2907210001-间苯二酚
2907221000-对苯二酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10793885-B2
优先权日:2013-08-16
标 题 :Compositions and methods for making noscapine and synthesis intermediates thereof
发明人：FACCHINI PETER JAMES; CHEN XUE; DANG THI THU THUY
权利人:WILLOW BIOSCIENCES INC
摘要:Methods for the manufacture of the therapeutic chemical compound noscapine and noscapine synthesis intermediates comprising contacting a noscapine pathway precursor selected from a first canadine derivative, a first papaveroxine derivative and narcotine hemiacetal with at least one of the enzymes selected from the group CYP82Y1, CYP82X1, AT1, CYP82X2, OMT, CXE1 and NOS.
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合成参考文献
参考文献:10.1111/tpj.13947
摘要:Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ. Heterodimeric O‐methyltransferases involved in the biosynthesis of noscapine in opium poppy. The Plant Journal. 2018 Jun 08;95(2):252–67. doi: 10.1111/tpj.13947.
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