CAS: 51200-87-4; 4,4-Dimethyloxazolidine

该化合物是一种杂交有机化合物,其特点是含有氮和氧原子的五人环,其特征是氧化氮环的4位置上附着的两组甲基化合物,这组物质具有独特的化学特性.该化合物一般没有色素,可粉黄,可能有微弱的气味;有机溶剂中可溶解,在标准条件下具有中等稳定性.4,4,4-二甲基氧化氮碘可以参与各种化学反应,包括核生殖替代和循环化过程,使其在有机合成中有用.其结构允许在制药,农用化学品和作为聚合物化学的建筑块方面的潜在应用.安全数据表明,与许多有机化合物一样,该化合物应谨慎处理,因为吸入或摄入该物质可能会对健康造成危害.实验室环境中与该物质打交道时,应遵循适当的安全议定书.

结构式图片

相似化合物

54013-55-7 26654-39-7 104499-08-3

物理性质

MSDS等安全信息

欧盟法规

REACH注册ECHA物质欧盟化妆品法规附录五-准用防腐剂清单ECHA物质C&L通报欧盟生物杀灭剂法规欧盟《生物杀灭剂法规》REACH预注册

合成工艺路线路线简述

    📜聚合甲醛,2-氨基-2-甲基-1-丙醇 以 苯 作为反应溶剂,化学反应生成 4,4-二甲基恶唑啉
    参考文献:Habermehl,G.,Chemische Berichte,1963,Vol. 96,P. 2029-2034
    标题:Habermehl,G.,Chemische Berichte,1963,Vol. 96,P. 2029-2034

    海关参考信息

    专利信息


    专利号:US-9458111-B2
    优先权日:2010-07-29
    标题:Process for the synthesis of substituted urea compounds
    发明人：LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS
    权利人:LEARMONTH DAVID ALEXANDER; BROADBELT BRIAN; WAHNON JORGE BRUNO REIS; BIAL—PORTELA & CA S A
    摘要:A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof: n nthe process comprising the reaction of a carbamate of Formula (II′): Formula (I′):n n nwith a primary or secondary amine of the formula R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

    专利号:US-2015197503-A1
    优先权日:2012-07-27
    标题 :Process for the synthesis of substituted urea compounds
    发明人：RUSSO DOMENICO; WAHNON JORGE BRUNO REIS; MATON WILLIAM; ESZENYI TIBOR
    权利人:BIAL PORTELA & Cª S A
    摘要:A process for preparing a substituted urea compound of Formula II or Formula I, or a pharmaceutically acceptable salt or ester thereof, Formula II, Formula I the process comprising the reaction of an intermediate of Formula II′ or Formula 1′, Formula II′, Formula I′ with a carbamoyl halide of the formula: R1R2NC(=0)Hal, in a solvent consisting essentially of pyridine, wherein Hal represents Cl, F, I or Br, and wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

    专利号:US-2013123493-A1
    优先权日:2010-07-29
    标题 :Process for the synthesis of substituted urea compounds

    专利号:WO-2014017938-A2
    优先权日:2012-07-27
    标题 :Process for the synthesis of substituted urea compounds

    专利号:EP-2606035-A1
    优先权日:2010-07-29
    标 题 :Proces for the synthesis of substituted urea compounds

    专利号:EP-2882712-A2
    优先权日:2012-07-27
    标题 :Process for the synthesis of substituted urea compounds

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    合成参考文献


    摘要:Cosmetics and Toiletries., 96(3)(79), 1981
    摘要:USEPA/CSPP; Methyloxazolidines. Reregistration Review: Final Work Plan. September 2012. USEPA-HQ-OPP-2012-0007. Washington, DC: US EPA, Chem Safe Poll Prevent. Available from, as of Dec 17, 2015:
    摘要:USEPA; Reregistration Eligibility Decision, 4,4-Dimethyloxazolidine p. 6-7 EPA-738-R-96-007 (August 1996). Available from, as of January 12, 2016:
    摘要:USEPA/OPPTS; Reregistration Eligibility Decisions (RED). 4,4-Dimethyloxazolidine. EPA-738-R-96-007. August 1996. Available from, as of Dec 17, 2015:
    摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
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