专利号:WO-2025081225-A1 优先权日:2023-10-17 标 题 :Synthesis of polyphenols 发明人:TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT 权利人:Delica Therapeutics Pty Ltd 摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.
专利号:US-2024026314-A1 优先权日:2020-11-25 标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds 发明人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN 权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN 摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.
专利号:EP-4251758-A1 优先权日:2020-11-25 标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds
专利号:WO-2022109736-A1 优先权日:2020-11-25 标题:Polypeptides for use in the synthesis of bioactive phenolic compounds
专利号:CA-3202377-A1 优先权日:2020-11-25 标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
参考文献:10.1093/ecam/neh139 摘要:Olalde Rangel JA, Magarici M, Amendola F, del Castillo O. The Systemic Theory of Living Systems. Part IV: Systemic Medicine—The Praxis. Evidence-Based Complementary and Alternative Medicine. 2005 Jan;2(4):429–39. doi: 10.1093/ecam/neh139.