CAS: 4481-62-3; 3-Oxolup-20(29)-En-28-Oic Acid

该化合物是一种自然产生的三元素化合物,产自树皮,特别是贝图拉物种,其特点是其具有单环结构,包括环球开球苯丙苯丙胺核心.该化合物显示白色到非白晶状外表,以其潜在的生物活动而闻名,包括抗炎和抗癌特性.(+)-贝图利尼酸在乙醇和氯仿等有机溶剂中溶解,但水溶性有限.其分子式反映了碳,氢和氧原子的具体安排,有助于其独特的化学行为.(+)称该化合物的立体化学学表明,该化合物有特定的空间安排,可能影响其生物互动.对(+)-贝托罗尼酸的研究继续探索其药理学潜力,使其成为自然产品化学和药学研究的一个对象.

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物理性质

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上下游产品

CAS号472-15-1 白桦脂酸 | CAS号473-98-3 白桦脂醇； 桦木醇 | CAS号13159-28-9 白桦脂醛 | CAS号7020-34-0 3-Oxobetulin | CAS号1721-69-3 桦木脑二乙酸 | CAS号1072913-62-2 (1R,3aS,5aR,5bR... | CAS号64-19-7 冰醋酸 | CAS号110-86-1 吡啶 | CAS号472-15-1 白桦脂酸 | CAS号38736-77-5 表白桦脂酸 | CAS号174022-42-5 贝韦立马 | CAS号150840-33-8 11-[[(1R,3aS,5a...

合成工艺路线路线简述

  • 合成目标产物 Betulonicacid 主要起始原料 Betulinic Acid
  • (文献来源)合成步骤主要原料 Betulinic Acid
📜Betulone置于jones Reagent体系中,化学反应生成 路路通酸
参考文献:白桦脂酸衍生物及其应用
标题:白桦脂酸衍生物及其应用
摘要:本发明属于医药领域,具体涉及白桦脂酸衍生物及其应用.本发明主要提供如下式i所示的化合物,其立体异构体,氮氧化物,药学上可接受的盐,或前药及其在制备药物中的用途,其中所述药物用于预防或治疗肝脏疾病,或者用于保护肝脏.

海关参考信息

专利信息


专利号:US-8865935-B2
优先权日:2011-06-30
标题:Purification methods for betulonic acid and Boc-lysinated betulonic acid, and organic synthesis of betulonic acid amides with piperazine derivatives
发明人：CHUE KUCK-TACK; KIM TAE-HWAN; TEN LEONID
权利人:CHUE KUCK-TACK; KIM TAE-HWAN; TEN LEONID; KOREA ENERGY RESEARCH INST
摘要:The present invention provides a method of purifying betulonic acid contained the reaction product of organic synthesis of a Jones oxidation reagent and betulin extracted from the bark of a birch, a method of preparing a piperazine betulonic acid amide derivative, which is used as a chemical having an antibacterial function, using the high-purity betulonic acid obtained by the purification method and a derivative prepared by this method, a method of purifying a Boc-lysinated betulonic acid monomer ester contained in the reaction product of organic synthesis of lysine and the high-purity betulonic acid (starting material) obtained by the purification method, and a method of purifying Boc-lysinated betulonic acid contained in the reaction product of hydrolysis of the high-purity Boc-lysinated betulonic acid monomer ester.

专利号:US-2009131714-A1
优先权日:2005-06-08
标题:Synthesis of betulonic and betulinic aldehydes
发明人：KRASUTSKY PAVEL A; MUNSHI KALYAN
权利人:KRASUTSKY PAVEL A; MUNSHI KALYAN
摘要:The present invention provides for methods of selectively converting betulin to betulonic aldehyde. The present invention also provides for methods of selectively converting 3-substituted triterpen-28-ols to the corresponding 3-substituted triterpen-28-carboxaldehydes. Additionally, the present invention provides for methods of preparing betulonic aldehyde, betulonic acid, betulinic acid, and corresponding 3-substituted triterpenes.

专利号:US-8969395-B2
优先权日:2009-05-20
标题 :Triterpenoid derivatives useful as antiproliferative agents
发明人：RIBEIRO SALVADOR JORGE ANTONIO; MENDES DOS SANTOS RITA CATARINA; CASCANTE SERRATOSA MARTA
权利人:RIBEIRO SALVADOR JORGE ANTONIO; MENDES DOS SANTOS RITA CATARINA; CASCANTE SERRATOSA MARTA; UNIV DE COIMBRA
摘要:Formula (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, for preventing and/or inhibiting tumor growth and for treating cancer and other proliferative diseases, more particularly for treating leukemia, liver, cervical, colon and prostate cancer. The present invention also relates to the synthesis of these compounds and to pharmaceutical compositions which contain them.

专利号:RU-2190622-C1
优先权日:2001-12-26
标 题 :Method of synthesis of betulinic acid

专利号:US-2014243527-A1
优先权日:2011-06-30
标题:Purification methods for betulonic acid and boc-lysinated betulonic acid, and organic synthesis of betulonic acid amides with piperazine derivatives

专利号:WO-2006133314-A2
优先权日:2005-06-08
标 题:Synthesis of betulonic and betulinic aldehydes

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主要参考文献

参考标题:Expedient Synthesis Of Alphitolic Acid And Its Naturally Occurring 2-O-Ester Derivatives
作者:Somin Park,Jihee Cho,Hongjun Jeon,Sang Hyun Sung,Seunghee Lee,Sanghee Kim |发布日期:2019.4.26
摘要:Expedient Synthesis Of Alphitolic Acid (1) As Well As Its Natural C-3-Epimer And 2- O-Ester Derivatives Was Accomplished In A Few Steps From The Readily Commercially Available Betulin (9). A Rubottom Oxidation Delivered An α-Hydroxy Group In A Stereo- And Chemoselective Manner. The Diastereoselective Reduction Of The α-Hydroxy Ketone Was Key To Accessing The 1,2-Diol Moiety Of This Class Of Natural Products

合成参考文献


参考文献:10.1016/s0960-894x(01)00460-7
摘要:Kim JY, Koo H, Kim DSHL. Development of C-20 modified betulinic acid derivatives as antitumor agents. Bioorganic & Medicinal Chemistry Letters. 2001 Sep;11(17):2405–8. doi: 10.1016/s0960-894x(01)00460-7.
参考文献:10.1016/j.bmcl.2004.04.010|10.1016/s0960-894x(04)00491-3
摘要:Mukherjee R, Jaggi M, Rajendran P, Srivastava SK, Siddiqui MJA, Vardhan A, Burman AC. Synthesis of 3-O-acyl/3-benzylidene/3-hydrazone/3-hydrazine/17-carboxyacryloyl ester derivatives of betulinic acid as anti-angiogenic agents. Bioorganic & Medicinal Chemistry Letters. 2004 Jun;14(12):3169–72. doi: 10.1016/j.bmcl.2004.04.010.
参考文献:10.1016/j.bmc.2006.05.048
摘要:Saxena BB, Zhu L, Hao M, Kisilis E, Katdare M, Oktem O, Bomshteyn A, Rathnam P. Boc-lysinated-betulonic acid: a potent, anti-prostate cancer agent. Bioorg Med Chem. 2006 Sep 15;14(18):6349–58. doi: 10.1016/j.bmc.2006.05.048.
参考文献:10.1007/s10517-005-0490-0
摘要:Zhukova NA, Semenov DE, Sorokina IV, Tolstikova TG, Pozdnyakova SV, Grek OR. Effect of Betulonic Acid and Its Derivative [3-Oxo-20(29)-Lupene-28-Oyl]-3-Aminopropionic Acid on Liver Structure in Mice with RLS Lymphoma. Bulletin of Experimental Biology and Medicine. 2005 Sep;140(3):361–4. doi: 10.1007/s10517-005-0490-0.
参考文献:10.1038/ja.2010.2
摘要:Alakurtti S, Bergström P, Sacerdoti-Sierra N, Jaffe CL, Yli-Kauhaluoma J. Anti-leishmanial activity of betulin derivatives. J Antibiot (Tokyo). 2010 Mar;63(3):123–6. doi: 10.1038/ja.2010.2.
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