CAS: 41613-26-7; 1,3-Dimethyl-5-Nitro-2,4(1H,3H)-Pyrimidinedione
该化合物是一种亚硝基罗皮米丁衍生物,其独特的结构特征,包括一个5位置的硝基罗集团和1和3位置的甲基替代物,该化合物因其作为生物活性分子准备的中间体的潜力,对合成有机化学和制药研究很感兴趣,其亚硝基米丁核心为进一步功能化提供了再活动,而二甲基组则增强了稳定性.该产品通常用于需要选择性地修改基环的受控反应中,其供应的纯度很高,以确保研究和工业应用的一致性.
- 英文名称1,3-Dimethyl-5-Nitro-2,4(1H,3H)-Pyrimidinedione
- 中文名称1,3-二甲基-5-硝基-2,4(1H,3H)-嘧啶二酮
- IUPAC名称1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione hydrate
- 其它别名1,3-二甲基-5-硝基嘧啶-2,4(1H,3H)-二酮; 1,3-Dimethyl-5-Nitrouracil Hydrate
- CAS编号41613-26-7
- MFCD编号:MFCD00167334
- EINECS号:255-462-8
- 分子式:C6H9N3O5分子量:203.15
- 产品CID: 1430274
- 产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: SDLBIQNBDPOOPJ-UHFFFAOYSA-N
- InChI=1S/C6H7N3O4.H2O/c1-7-3-4(9(12)13)5(10)8(2)6(7)11;/h3H,1-2H3;1H2
- 计算化学: 氢键受体数6.0氢键供体数*可旋转键数1.0
相似化合物
25912-37-2 28495-88-7 55326-07-3物理性质
MSDS等安全信息
上下游产品
CAS号611-08-5 5-硝基尿嘧啶 | CAS号74-88-4 碘甲烷 | CAS号74-83-9 溴甲烷 | CAS号874-14-6 1,3-二甲基尿嘧啶 | CAS号108047-30-9 3-methyl-1-(4-n... | CAS号74-89-5 氨基甲烷 | CAS号75-04-7 乙胺 | CAS号108070-70-8 5,6-dihydro-3-m... | CAS号96-31-1 1,3-二甲基脲 | CAS号74115-55-2 6-nitropyridopy... | CAS号58-55-9 茶碱 | CAS号16952-91-3 Acetamide,N-(1,... | CAS号58-08-2 咖啡因 | CAS号64732-10-1 5-hydroxy-1,3-d... | CAS号72078-82-1 N-甲基-2-硝基-乙酰胺 | CAS号78999-61-8 1-甲基-2,4-二氧代-1,... | CAS号49738-24-1 5-氨基-1,3-二甲基嘧啶-... | CAS号505-21-5 Hexahydropyrimidine合成工艺路线路线简述
📜3-Methyl-5-Nitro-1-Phenyluracil置于硝酸体系中,用 甲醇,硫酸 作为反应溶剂,化学反应 1.0H,反应生成 1,3-二甲基-5-硝基尿嘧啶水合物
参考文献:在5位上具有吸电子基团的尿嘧啶衍生物与胺的新反应:尿嘧啶n 1部分与胺之间的交换反应
标题:在5位上具有吸电子基团的尿嘧啶衍生物与胺的新反应:尿嘧啶n 1部分与胺之间的交换反应
摘要:具有在5-位的吸电子基团例如硝基,氨基甲酰基和氰基的1,3-二取代的尿嘧啶与伯胺的反应导致尿嘧啶环的n 1部分与胺部分交换.交换反应受5-和n 1-位上取代基的性质影响.用加成,开环和闭环的方式解释反应顺序.
DOI:10.1039/p19900000367
海关参考信息
- 2904209090-其他仅含硝基或亚硝基衍生物
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8623880-B2
优先权日:2009-03-23
标 题 :Fused pyrimidine-dione derivatives as TRPA1 modulators
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; DESHMUKH VISHAL GOVINDRAO; DHONE SACHIN VASANTRAO; CHIKHALE RAJENDRA PRAKASH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
权利人:CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; DESHMUKH VISHAL GOVINDRAO; DHONE SACHIN VASANTRAO; CHIKHALE RAJENDRA PRAKASH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL; GLENMARK PHARMACEUTICALS SA
摘要:The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.
专利号:US-9000159-B2
优先权日:2009-03-23
标 题 :Fused pyrimidine-dione derivatives as TRPA1 modulators
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; DESHMUKH VISHAL GOVINDRAO; DHONE SACHIN VASANTRAO; CHIKHALE RAJENDRA PRAKASH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
权利人:GLENMARK PHARMACEUTICALS SA; GLENMARK PHARMACEUTICALS SA
摘要:The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1007/bf01172867
摘要:van der Plas HC. Thirty years of pyrimidine chemistry in the laboratory of organic chemistry at the Wageningen Agricultural University, The Netherlands (review). Chemistry of Heterocyclic Compounds. 1994 Nov;30(11-12):1427–43. doi: 10.1007/bf01172867.
参考文献:10.1007/10407393_58
摘要:Wierzchowski KL. 4.11.2 Data. 1990. In: Physical Data II. Theoretical Investigations. : Springer-Verlag; 1990.
📝 需求与反馈
尽可能描述清楚需求与问题信息
