CAS: 398-71-0; 2-Ethyl-4-Fluorophenol

该化合物是一种氟化酚化合物,其特点是在苯酚环的4位置有一个乙基组,在2位置有一个氟原子,在苯酚环的4位置有一个氟原子.这种结构配置具有独特的电子和不育特性,使其成为有机合成中的宝贵中间体,特别是在开发药品,农用化学品和特殊化学品方面.氟化物替代会增强代谢稳定性和亲脂性,而乙基组则会助长消毒障碍,影响再活动性和选择性.其高纯度和一贯的质量确保了要求应用的可靠性能,如交叉反应和功能性组变.该化合物通常在受控制的条件下因反应性而处理.

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CAS号850793-83-8 1-(2-羟基-5-氟苯基)乙醇 | CAS号324-44-7 2-ethyl-4-fluor... | CAS号577-97-9 1-(2-ethoxy-5-f... | CAS号394-32-1 5-氟-2-羟基苯乙酮

合成工艺路线路线简述

    📜5-氟-2-羟基苯乙酮置于三乙基硅烷,Sodium Tetrahydroborate,三氟乙酸体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 3.0H,反应生成2-乙基-4-氟苯酚
    参考文献:Ep3907218
    标题:Ep3907218

    海关参考信息

    专利信息


    专利号:WO-2009081259-A1
    优先权日:2007-12-21
    标题 :Phenoxy-pyridyl derivatives
    发明人:BARTA NANCY SUE; CAMPBELL BRIAN MICHAEL; DOUNAY AMY BETH; GRAY DAVID LAWRENCE FIRMAN; ZORN STEVIN HOWARD
    权利人:PFIZER; BARTA NANCY SUE; CAMPBELL BRIAN MICHAEL; DOUNAY AMY BETH; GRAY DAVID LAWRENCE FIRMAN; ZORN STEVIN HOWARD
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-2012053165-A1
    优先权日:2009-03-03
    标 题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
    发明人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG
    权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/bf00951216
    摘要:Teitel'baum AB, Kudryavtseva LA, Bel'skii VE, Ivanov BE. Basicity of o-aminomethylphenols in nonaqueous media. Russian Chemical Bulletin. 1980 Oct;29(10):1571–80. doi: 10.1007/bf00951216.
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