CAS: 3554-90-3; 2-(Acetylamino)-2-Deoxy-3-O-Beta-D-Galactopyranosyl-D-Galactose

上下游产品

D-Mannose N-acetylgalactosamine uridine 5'-diphospho-D-galactose 4-methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranosideD-Galactose 2-acetamido-3,6-anhydro-2-deoxy-α-D-idofuranose 2-acetamido-3,6-anhydro-2-deoxy-α-D-gulofuranose sialyl-T antigen

口服葡萄糖置于d-Galactosyl-β1-3-N-Acetyl-D-Hexosamine Phosphorylase,Galactose Kinase From Bifidobacterium Infantis体系中,化学反应生成 Beta-D-半乳糖基-(1->3)-N-乙酰基-D-半乳糖胺
参考文献:Two-Step Chemoenzymatic Detection Of N-Acetylneuraminic Acid−α(2-3)-Galactose Glycans
标题:Two-Step Chemoenzymatic Detection Of N-Acetylneuraminic Acid−α(2-3)-Galactose Glycans
摘要:Sialic Acids Are Typically Linked Alpha(2-3) Or Alpha(2-6) To The Galactose That Located At The Non-Reducing Terminal End Of Glycans,Playing Important But Distinct Roles In A Variety Of Biological And Pathological Processes. However,Details About Their Respective Roles Are Still Largely Unknown Due To The Lack Of An Effective Analytical Technique. Herein,A Two-Step Chemoenzymatic Approach For The Rapid And Sensitive Detection Of N-Acetylneuraminic Acid-Alpha(2-3)-Galactose Glycans Is Described.
DOI:10.1021/jacs.6B07132

专利信息

专利号:WO-2023023585-A1
优先权日:2021-08-18
标题 :Genetically engineered tumor-specific effector cells for synthesis of enzymes
发明人：BHATNAGAR PARIJAT; RADHAKRISHNAN HARIKRISHNAN
权利人:STANFORD RES INST INT
摘要:An example genetically engineered effector cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) including an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes an antigen on a surface of a tumor cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an enzyme configured to reduce a tumor-associated extracellular matrix (ECM) associated with the tumor cell. The effector element encodes the enzyme, wherein in response to the extracellular antigen binding domain of the CAR binding to the antigen of tumor cell, the genetically engineered effector cell is configured to activate and, to synthesize and secrete the enzyme to a tumor microenvironment (TME) associated with the tumor cell.

专利号:US-6156547-A
优先权日:1990-04-16
标 题:Apparatus for the synthesis of saccharide compositions
发明人：ROTH STEPHEN
权利人:NEOSE PHARM INC
摘要:This invention relates to an apparatus containing specific binary combinations of glycosyltransferases, for the synthesis of specific saccharide compositions such as, for example, oligosaccharides, polysaccharides, glycolipids, and glycopeptides.

专利号:US-2023221331-A1
优先权日:2020-01-24
标题:Identification And Synthesis Of Drug Candidates Derived From Human Microbiome Metasecretome Proteins
发明人：CHENE LAURENT; STROZZI FRANCESCO; BONNY CHRISTOPHE
权利人:ENTEROME S A
摘要:The present invention relates to the treatment of diseases relating to proteins of the human microbiome metasecretome and, thus, to microbiome interactions, especially microbiome-host interactions. In particular the present invention relates to a method for identification of secreted peptides and proteins of the human microbiome. The present invention also relates to methods for generating a database of human microbiome metasecretome protein sequences. Furthermore, the present invention relates to a method for preparing a protein of the human microbiome metasecretome as well as to the use of such proteins in medicine.

专利号:US-2024409571-A1
优先权日:2023-06-08
标 题:Chemoenzymatic synthesis of n-acetylated gangliosides and glycosphingosines
发明人：CHEN XI; YU HAI; MISHRA BIJOYANANDA; ZHENG ZIMIN; AGRAHARI ANAND KUMAR; GUCCHAIT ARIN
权利人:UNIV CALIFORNIA
摘要:Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.

专利号:WO-8705936-A1
优先权日:1986-04-02
标 题 :Process for the manufacture of oligosaccharides
发明人：JOHANSSON HANNA MARIA ELISABET; HEDBYS LARS OLOF; LARSSON PER-OLOF; MOSBACH KLAUS; GUNNARSSON ALF GUNNAR INGEMAR; SVENSSON SIGFRID EDVIN
权利人:JOHANSSON HANNA MARIA E; HEDBYS LARS OLOF; LARSSON PER OLOF; MOSBACH KLAUS; GUNNARSSON ALF GUNNAR INGEMAR; SVENSSON SIGFRID EDVIN
摘要:A process for enzymatic synthesis of oligosaccharides starting from lower building stones down to monomers, characterized by performing reverse hydrolysis in the presence of a glycosidase by carrying out the reaction in a solution having a high substrate content, i.e. a low water content.

专利号:WO-2004041310-A1
优先权日:2002-11-08
标题:Preparation of chemically well-defined carbohydrate dendrimer conjugates
发明人：HEEGAARD PETER; BOAS ULRIK
权利人:DANMARKS FOEDEVARE OG VETERINA; HEEGAARD PETER; BOAS ULRIK
摘要:A method for the synthesis of dendrimer conjugates having a well-defined chemical structure, comprising one or more carbohydrate moieties and one or more immunomodulating substances coupled to a dendrimer, is presented. First, the carbohydrate is bound to the dendrimer in a chemoselective manner. Subsequently, the immunomodulating substance is also bound in a chemoselective manner, to give a dendrimer conjugate with a well-defined structure and connectivity and containing a precise, pre-determined ratio of carbohydrate to immunomodulating substance. The invention also relates to novel dendrimer conjugates and their use in vaccination, production of antibodies, high throughput screening, diagnostic assays and libraries.