CAS: 22204-91-7; (1-Methylpiperidin-4-yl) 2,2-Bis(4-Chlorophenoxy)Acetate

专利信息

专利号:US-12427148-B2
优先权日:2018-04-28
标 题:Cancer treatment targeted to tumor adaptive responses to protein synthesis stress
发明人：RUGGERO DAVIDE; NGUYEN HAO; CARROLL PETER; CONN CRYSTAL
权利人:UNIV CALIFORNIA
摘要:In cancers such as prostate cancer, the combination of PTEN loss and activation of Myc activates an adaptive stress response that enables tumor cells to escape the stress of massively upregulated protein synthesis. This pro-survival response is mediated by the PERK-phosphorylated eIF2α axis of the UPR adaptive response. Agents that disrupt PERK-eIF2α pathways disrupt the adaptive response and lead to cancer cell death from uncontrolled growth. For example, ISRIB and derivatives may be employed as therapeutic agents to disrupt PERK-mediated adaptive mechanisms. Additionally PTEN loss and activation of Myc provides a diagnostic marker that enables better prognosis and the selection of amenable treatments.

专利号:CN-101974034-B
优先权日:2010-10-18
标题 :Synthesis of Flavonoid Alkyl Phosphate Compounds and Their Application in Cholesterol Esterase Inhibitors

专利号:CN-101974034-A
优先权日:2010-10-18
标 题 :Synthesis of Flavonoid Alkyl Phosphate Compounds and Their Application in Cholesterol Esterase Inhibitors

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.