CAS: 2127-10-8; 1,2-Bis(5-Nitropyridin-2-yl)Disulfane

相似化合物

2127-11-9 130156-01-3 1887238-64-3

上下游产品

CAS号2127-09-5 2-巯基-5-硝基吡啶 | CAS号4548-45-2 2-氯-5-硝基吡啶 | CAS号27885-56-9 3-氨基-6-疏基吡啶 | CAS号2127-09-5 2-巯基-5-硝基吡啶 | CAS号174485-82-6 5-硝基吡啶-2-磺酰氯

2-羟基-5-硝基吡啶置于劳森试剂,Sodium Hydroxide体系中,用 2-甲基-2-丁醇,水 用作溶剂,化学反应 0.5H,反应生成2,2'-二硫双(5-硝基吡啶)
参考文献:If 5影响cl-F交换氟化的最后阶段中的五氟-λ合成6硫烷基-吡啶,嘧啶和苯与吸电子取代基
标题:If 5影响cl-F交换氟化的最后阶段中的五氟-λ合成6硫烷基-吡啶,嘧啶和苯与吸电子取代基
摘要:在五氟λ的制备的最后阶段甲难以氯-氟(cl-F)交换氟化反应6具有吸电子取代基-Sulfanyl-(杂)芳烃现已通过使用五氟化碘的阐明.F和i与卤素键之间的潜在相互作用充分抑制了cs键断裂的主要副反应.
Doi:10.1039/c7Cc02802D

专利信息

专利号:US-7691968-B2
优先权日:2002-05-03
标题:Process for the synthesis of peptides amides by side-chain attachment to a solid phase
发明人：EVANS DAVID JOHN; SIMPKIN DEAN STEVEN ANTHONY; WELLINGS DONALD ALFRED; ATHERTON ERIC
权利人:AVECIA BIOLOG LTD
摘要:A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.

专利号:US-6090934-A
优先权日:1996-10-20
标 题:Universal support for the synthesis of oligonucleotides
发明人：KUMAR PRADEEP; GUPTA KAILASH CHAND
权利人:COUNCIL SCIENT IND RES; DBT GOVERNMENT OF INDIA
摘要:A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer support through a covalent linkage and the other hydroxyl group is protected by an acid labile group.

专利号:US-7781488-B2
优先权日:2002-06-10
标 题:Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:US-7456309-B2
优先权日:2004-12-16
标 题:Reusable universal polymer support for repetitive oligonucleotide synthesis
发明人：KUMAR PRADEEP; GUPTA KAILASH CHAND
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides a reusable, universal polymer support for repetitive oligonucleotide synthesis and a method of synthesis thereof.

专利号:US-2008051323-A1
优先权日:2004-08-21
标 题 :Chloroquine drug compositions and methods for their synthesis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. n The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.

专利号:US-2007060499-A1
优先权日:2005-09-15
标 题 :Chloroquine combination drugs and methods for their synthesis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.