CAS: 20698-91-3; (R)-Methyl 2-Hydroxy-2-Phenylacetate

该化合物是属于甲酸酯类的有机化合物,其特征是其性能,其特征是其性能,其(R)-抗抗生素是其特殊组合.该化合物一般看起来无色可粉黄色液体,有美味的果味味.甲基(R--)-mandelate在乙醇和乙醚等有机溶剂中是可溶性,但由于其缺水的甲基酯类,其溶解性有限.该化合物经常用于合成药物和有机化学的手力构件,因为它能够参与非对称合成.此外,该化合物还可在各种反应中起到助力作用,增强理想产品的选择性.该化合物还因其芳香性特性而在口味和香味化学领域也引起兴趣.安全数据表明,与许多有机化合物一样,它应当谨慎处理,避免吸入和皮肤接触.

结构式图片

上下游产品

CAS号15206-55-0 苯甲酰甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号611-71-2 扁桃酸 | CAS号22979-35-7 methyl phenyldi... | CAS号4358-87-6 DL-扁桃酸甲酯 | CAS号77-76-9 2,2-二甲氧基丙烷 | CAS号86013-39-0 2-(((R)-4-oxope... | CAS号74-88-4 碘甲烷 | CAS号186581-53-3 重氮甲烷 | CAS号3966-32-3 (R)-(-)-alpha-甲氧基苯乙酸 | CAS号95061-46-4 (|R|)-(+)-1,1,2... | CAS号42540-40-9 头孢孟多酯钠 | CAS号95061-47-5 (R)-(+)-2-羟基-1,... | CAS号15028-39-4 (S)-(+)-2-苯基甘氨酸甲酯 | CAS号19883-41-1 D-苯甘氨酸甲酯盐酸盐 | CAS号16355-00-3 (R)-(-)-1-苯基-1,2-乙二醇 | CAS号25779-13-9 (S)-1-苯基-1,2-乙二醇 | CAS号611-71-2 扁桃酸 | CAS号2549-14-6 (R)-2-氨基-1-苯乙醇

合成工艺路线路线简述

    Dl-扁桃酸甲酯 反应生成(R)-(-)-扁桃酸甲酯
    参考文献:Kanerva,Liisa T.; Sundholm,Oskari,Acta Chemica Scandinavica,1993,Vol. 47,# 8,P. 823-825
    标题:Kanerva,Liisa T.; Sundholm,Oskari,Acta Chemica Scandinavica,1993,Vol. 47,# 8,P. 823-825

    海关参考信息

    专利信息


    专利号:WO-2023012205-A1
    优先权日:2021-08-05
    标 题 :Synthesis of specific butyrate compounds
    发明人:BONRATH WERNER; GOETZINGER ALISSA; PACE FRANCESCO; WUESTENBERG BETTINA
    权利人:DSM IP ASSETS BV
    摘要:The present invention relates to new specific butyrate compounds to a new and improved synthesis of specific butyrates as well their use. Butyrate compounds are very useful compounds, either as such or as intermediates in organic synthesis.

    专利号:US-8304540-B2
    优先权日:2007-05-18
    标题:Process for stereoselective synthesis of lamivudine
    发明人:LI JINLIANG; LV FENG
    权利人:LI JINLIANG; LV FENG; SHANGHAI DESANO PHARMACEUTICAL HOLDING CO LTD
    摘要:The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.

    专利号:US-11370736-B2
    优先权日:2019-04-01
    标 题:Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation
    发明人:DUB PAVEL A; BATRICE RAMI J; GORDON JOHN C
    权利人:TRIAD NAT SECURITY LLC
    摘要:This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

    专利号:US-5399721-A
    优先权日:1990-01-12
    标题:Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
    发明人:HOPPER ALLEN T; WITIAK DONALD T
    权利人:UNIV OHIO STATE RES FOUND
    摘要:The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. the invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.

    专利号:US-5656662-A
    优先权日:1990-01-12
    标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
    发明人:MANTRI PADMAJA; WITIAK DONALD T
    权利人:UNIV OHIO STATE RES FOUND
    摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.

    专利号:US-6384228-B2
    优先权日:1998-05-26
    标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
    发明人:NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
    权利人:NIHON MEDIPHYSICS CO LTD
    摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.
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    合成参考文献


    摘要:Kashemirov, B. A.; Błażewska, K.; Justyna, K.; Lyu, J.; McKenna, C. E., Science of Synthesis Knowledge Updates, (2021) 1, 378.
    摘要:Bertau, M.; Jeromin, G. E., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 178.
    摘要:Matsunami, A.; Kayaki, Y.; Ikariya, T., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 72.
    参考文献:10.1007/s12010-007-8125-8
    摘要:Wei H, Wu B. Screening and Immobilization Burkholderia sp. GXU56 Lipase for Enantioselective Resolution of (R,S)-Methyl Mandelate. Applied Biochemistry and Biotechnology. 2008 Jan 26;149(1):79–88. doi: 10.1007/s12010-007-8125-8.
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