CAS: 19725-47-4; 2-(2-Methoxyphenyl)Chromen-4-One

该化合物是一种合成的弗拉夫尼衍生物,其特点是在弗拉夫尼主干骨的2'位置存在一个甲氧基组,这种改变增强了其稳定性并影响其物理化学特性,使其成为有机合成和制药研究的宝贵中间体.复合物具有与自然产生的氟氯素结构相似的潜在生物活性,后者以其抗氧化和防炎特性而著称.其定义明确的结构和纯度使它适合用于机械学研究,药物开发以及作为分析化学的参考标准.甲基氧代用品还提高了有机溶剂的溶性,促进了其在各种实验协议中的应用.

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1-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)-propane-1,3-dione sodium acetate acetic acid 2,3-dihydro-2-(2-methoxyphenyl)-4H-1-benzopyran-4-one 3-iodo-2-(2-methoxyphenyl)chromone 2-(2-Methoxyphenyl)-4-oxo-4H-1-benzopyran-3-carboxylic acid 2'-hydroxyflavone

合成工艺路线路线简述

    📜4-Hydroxycoumarin置于吡啶,Dipotassium Hydrogenphosphate体系中,用 二氯甲烷,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 14.0H,反应生成2'-甲氧基黄酮
    参考文献:一种长余辉蓄光型有机发光材料及其制备方法
    标题:一种长余辉蓄光型有机发光材料及其制备方法
    摘要:本发明涉及有机合成技术领域,尤其涉及一种长余辉蓄光型有机发光材料及其制备方法.本发明公开了一种具有式(ⅰ)所示结构的长余辉蓄光型有机发光材料的制备方法,该制备方法反应原料廉价易得,制备成本较低;该制备方法操作简单,反应路线新颖,反应时间和合成路线短,反应条件温和,反应体系干净,安全性高,且能以极高的收率和选择性得到式(ⅰ)所示结构长余辉蓄光型有机发光材料;该制备方法避免了剧烈的高温条件,剧毒试剂以及昂贵金属催化剂的使用,制备方法绿色经济;该制备方法后处理方式简单,纯化损失少,极大地节约了人力,物力和时间,能够适应和满足工业化生产的需求.

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    专利信息


    专利号:EP-1493431-B1
    优先权日:2003-07-03
    标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions
    发明人:WIRTH CORINNA DR; BUCHHOLZ HERWIG DR
    权利人:MERCK PATENT GMBH
    摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.

    专利号:US-2010160351-A1
    优先权日:2008-12-19
    标题:Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
    发明人:JENKINS HELEN; KITT MICHAEL; PEARLMAN RODNEY; SERAFINI TITO; THORSETT EUGENE
    权利人:NUON THERAPEUTICS INC
    摘要:Disclosed is a pharmaceutical composition comprising (a) a first therapeutic agent, wherein the first therapeutic agent is a compound of formula II: n n n n n n n n n n n n or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , X and n are as defined herein; (b) a second therapeutic agent, wherein the second therapeutic agent is a uric acid synthesis inhibitor or a uricosuric agent; and (c) a pharmaceutically acceptable diluent or carrier.

    专利号:CN-109321543-A
    优先权日:2018-11-02
    标 题 :The oxygen transmethylase and its encoding gene of participation orange peel flavones synthesis and application

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, .
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