CAS: 196085-85-5; Tert-Butyl 2-((4S,6S)-6-(Cyanomethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate

相似化合物

124752-23-4 196085-84-4 1357600-18-0

上下游产品

tert-butyl (3S,5S)-6-cyano-3,5-dihydroxyhexanoate 2,2-dimethoxy-propane tert-butyl (4S,6S)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate

📜1,6-庚二烯-4-醇置于chromium(Vi) Oxide,4-二甲氨基吡啶,正丁基锂,硫酸,对甲苯磺酸,高碘酸,间氯过氧苯甲酸,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,乙醚,二氯甲烷,二甲基亚砜,丙酮 用作溶剂,化学反应 125.0H,反应生成2-甲基-2-丙基[(4S,6S)-6-(氰基甲基)-2,2-二甲基-1,3-二恶烷-4-基]乙酸酯
参考文献:改进的1,1-二甲基乙基6-氰基甲基-2,2-二甲基-1,3-二恶烷-4-乙酸酯的合成,这是阿托伐他汀合成的关键中间体
标题:改进的1,1-二甲基乙基6-氰基甲基-2,2-二甲基-1,3-二恶烷-4-乙酸酯的合成,这是阿托伐他汀合成的关键中间体
摘要:描述了一种改进的1,1-二甲基乙基6-氰基甲基-2,2-二甲基-1,3-二恶烷-4-乙酸酯的合成,其是合成有效的hmg-Coa还原酶抑制剂阿托伐他汀的关键中间体.该合成基于庚七,1,6-二烯-4-醇到4-烯丙基-6-碘甲基-1,3-二恶烷-2-酮的碘内酯化,该过程可分几步转化为(6-烯丙基-2,2-二甲基-1,3-二恶烷-4-基)-乙腈.该中间体通过相应的醛或通过(2,2-二甲基-6-环氧乙烷基甲基-1,3-二恶烷-4-基)乙腈.
Doi:10.1016/s0040-4039(02)00175-2

专利信息

专利号:US-5248793-A
优先权日:1990-10-17
标 题:Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
发明人：MILLAR ALAN; BUTLER DONALD E
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate is described where a hydroxy ester derivative is converted in two steps to the desired product, as well as valuable intermediates used in the process.

专利号:US-5280126-A
优先权日:1988-02-22
标题 :Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-Y-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5216174-A
优先权日:1988-02-22
标题:Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3carboxamide by a novel synthesis where 4-methyl-3-oxoN-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1Hpyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5097045-A
优先权日:1989-02-01
标题 :Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5149837-A
优先权日:1988-02-22
标题 :Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(±)-5-(4-fluoro-phenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

专利号:US-5124482-A
优先权日:1988-02-22
标题:Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
发明人：BUTLER DONALD E; DEERING CARL F; MILLAR ALAN; NANNINGA THOMAS N; ROTH BRUCE D
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien-4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans(±)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide by a novel synthesis where 4-methyl-3-oxo-N-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzenebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.