CAS: 1879-16-9; 4-Methoxythioanisole

该化合物是含有硫磺的芳香化合物,配有分子式C8H10OS,其特点是甲氧基化合物和苯环上的硫醚细胞类替代物,在有机合成中具有独特的再活性.该化合物是制备药品,农用化学品和特殊化学品的一个多用途中间体.其电子富含芳香系统可促进电益替代反应,而硫醚类群体可参与进一步的功能化.P-Methoxythioaniole因其稳定性,易操作性和与一系列反应条件的兼容性而备受重视,使其成为合成化学中有用的建筑块.建议在惰性条件下妥善储存,以保持纯度.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号696-62-8 4-碘苯甲醚 | CAS号67-68-5 二甲基亚砜 | CAS号3517-99-5 1-甲氧基-4-(甲基亚磺酰基)苯 | CAS号636-98-6 4-硝基碘苯 | CAS号74-83-9 溴甲烷 | CAS号624-92-0 二甲基二硫醚 | CAS号104-94-9 对甲氧基苯胺 | CAS号15436-21-2 Benzenesulfonam... | CAS号696-63-9 对甲氧基苯硫酚 | CAS号74-88-4 碘甲烷 | CAS号3517-90-6 4-甲氧基苯急家基砜 | CAS号3517-99-5 1-甲氧基-4-(甲基亚磺酰基)苯 | CAS号1445-91-6 (S)-(-)-1-苯基乙醇 | CAS号1517-69-7 (R)-(+)-1-苯基乙醇 | CAS号53040-92-9 4-甲氧基-4-甲基-联苯 | CAS号1193-82-4 苯亚砜甲酯 | CAS号934-71-4 1-溴-4-(甲亚磺酰基)苯 | CAS号5345-30-2 (2E)-3-[4-(甲基磺酰...

合成工艺路线路线简述

  • 合成目标产物 1-Methoxy-4-(Methylthio)Benzene 主要起始原料 Dimethyl Disulfide And 4-Iodoanisole
  • (文献来源)合成步骤主要原料 Dimethyl Disulfide 和 4-Iodoanisole
1,4-二氯苯 以 N,N-二甲基甲酰胺 用作溶剂,化学反应 41.0H,反应生成4-甲氧基茴香硫醚
参考文献:Simple Syntheses Of Aryl Alkyl Thioethers And Of Aromatic Thiols From Unactivated Aryl Halides And Efficient Methods For Selective Dealkylation Of Aryl Alkyl Ethers And Thioethers
标题:Simple Syntheses Of Aryl Alkyl Thioethers And Of Aromatic Thiols From Unactivated Aryl Halides And Efficient Methods For Selective Dealkylation Of Aryl Alkyl Ethers And Thioethers
摘要:
Doi:10.1055/s-1983-30501

海关参考信息

专利信息


专利号:US-6207838-B1
优先权日:1999-04-30
标 题 :Electrochemically generated organothiating reagents and their use
发明人:GLASS RICHARD S; JOUIKOV VIATCHESLAV V
权利人:UNIV ARIZONA
摘要:Electrolysis of organic disulfides in liquid sulfur dioxide is used to obtain organothiating agents, which can then be reacted with appropriate substrates to effect the synthesis of organothioaromatic compounds efficiently and in high yields. With appropriate phenolic compounds, regioselective substitution occurs in which para substitution greatly exceeds ortho substitution.

专利号:US-4996314-A
优先权日:1986-03-11
标题 :6-(disubstituted amino)carbapenem compounds
发明人:YOSHIOKA TAKEO; CHIDA NORITAKA; WATANABE AZUMA; FUKAGAWA YASUO; ISHIKURA TOMOYUKI
权利人:SANRAKU INC
摘要:A compound represented by the formula ##STR1## wherein R 1 represents a lower alkyl group or a lower haloalkyl group; R 2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR 4 or --SO 2 R 5 in which R 4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R 5 represents an alkyl group or a substituted or unsubstituted aryl group; and R 3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic. n The compounds of the formula ##STR2## wherein R 1 and R 2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.

专利号:US-5721255-A
优先权日:1992-08-19
标 题 :Substituted benzylamino nitrogen containing non-aromatic heterocycles
发明人:HOWARD HARRY R; NAKANE MASAMI; IKUNAKA MASAYA; SATAKE KUNIO; ROSEN TERRY J; LOWE III JOHN A; O'NEILL BRIAN T; ITO FUMITAKA
权利人:PFIZER
摘要:The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R 1 , R 2 , R 3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

专利号:US-8367871-B2
优先权日:2007-03-09
标 题 :Process for production of optically active sulfoxide compound using iron-salan complex catalyst
发明人:KATSUKI TSUTOMU; EGAMI HIROMICHI
权利人:NISSAN CHEMICAL IND LTD; KATSUKI TSUTOMU; EGAMI HIROMICHI
摘要:An optically active sulfoxide compound that is useful as an intermediate for synthesis or an active ingredient of a physiologically active substance such as a pharmaceutical agent is produced at a high optical purity. A process for producing an optically active sulfoxide compound of formula (4) comprises oxidizing a sulfide compound of formula (3) in the presence of an optically active metal complex of formula (1), (1′), (2) or (2′) by using an oxidizing agent. The present invention is also directed to the optically active metal complex.

专利号:CN-116969875-A
优先权日:2023-07-21
标题:Synthesis method of thioester functionalized 2-oxoindole

专利号:CN-115557985-B
优先权日:2022-12-06
标 题 :A kind of method of C-S bond synthesis silane in selective cracking thioether
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✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: U Pérez, Et Al. Transient-State Kinetics Of The Reactions Of 1-Methoxy-4-(Methylthio)Benzene With Horseradish Peroxidase Compounds I And Ii. Biochemistry. 1990 Mar 20;29(11):2757-63.

合成参考文献


摘要:Barsegyan, Y. A.; Vil’, V. A.; Tomkinson, N. C. O.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2022) 1, 266.
摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 1010.
摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 989.
摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 1000.
摘要:Lattanzi, A., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 1006.
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