CAS: 1758-33-4; (2R,3S)-2,3-Dimethyloxirane

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上下游产品

3-chlorobutan-2-ol acetic acid-(2-chloro-1-methyl-propyl ester) 3-bromo-2-butanol trans-2-Butenetert-Amyl alcohol butanone 2.3-butanediol 3-(1-Methyl-1-phenyl-ethylperoxy)-butan-2-ol

专利信息

专利号:US-9267213-B1
优先权日:2005-03-25
标题:Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
发明人：MAURER KARL; COOPER JOHN J
权利人:CUSTOMARRAY INC
摘要:There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

专利号:US-2009081801-A1
优先权日:2007-08-15
标题:Process for synthesis of pyrrole derivative, an intermediate for atorvastatin
发明人：KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; PATEL HITESH K; RAO V GOVARDHAN; DAUND VAIBHAV S
权利人:KANSAL VINOD KUMAR; CHAURASIA BRIJNATH P; PATEL HITESH K; RAO V GOVARDHAN; DAUND VAIBHAV S
摘要:The present invention also relates to a novel impurity, (6-{2-[2-(6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)-acetylamino]-ethyl}-2,2-dimethyl-[1,3]-dioxan-4-yl)-acetic acid tert-butyl ester, the compound of formula IV, having the following structure: n n n n n n n n n n The present invention also provides methods of preparing the compound of formula IV as well as methods of using the compound of formula IV as a reference marker and a reference standard. n The present invention also provides an improved process for preparing (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester, the compound of formula I, said process comprising the step of condensing 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N,β-diphenylbenzene butanamide, the compound of formula III, with (4R,Cis)-1,1-dimethylethyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, the compound of formula II, in the presence of a catalytic amount of an acid in the presence of a solvent system, preferably a binary solvent system, to obtain the desired compound (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester.

专利号:US-6653501-B2
优先权日:2001-06-27
标题 :Chiral resolution method for producing compounds useful in the synthesis of taxanes
发明人：MCCHESNEY JAMES D; BRINKMAN HERBERT R; ZEGAR SIEAD; BAEHR DAVID
权利人:NAPRO BIOTHERAPEUTICS INC
摘要:A method is provided for processing a solution having optical isomers to obtain a (2R,3S) target isomer:wherein P1 is H or a hydroxyl protecting group, R1 is H, an alkyl group, an olefinic group or an aromatic group, and R2 is H or R3CO, where R3 is an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group or an O-aromatic group, provided that R<1 >is not H when R<3 >is Ph and P<1 >is H. The method includes passing the solution through a chromatographic stationary phase, such as S,S Whelk-O, that has a greater affinity for one of the target isomer and an optical isomer thereof. A portion of the solution with the target isomer is then collected. The solution may be a racemic mixture of (±)-N-CBZ-3-phenylisoserine ethyl ester.

专利号:US-9724682-B2
优先权日:2013-02-26
标 题 :Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer
发明人：BETLEY THEODORE ALEXANDER; HENNESSY ELISABETH THERESE
权利人:HARVARD COLLEGE
摘要:The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.

专利号:US-6986818-B2
优先权日:2000-06-02
标题 :Method for producing nanostructured metal-oxides
发明人：TILLOTSON THOMAS M; SIMPSON RANDALL L; HRUBESH LAWRENCE W; GASH ALEXANDER
权利人:UNIV CALIFORNIA
摘要:A synthetic route for producing nanostructure metal-oxide-based materials using sol-gel processing. This procedure employs the use of stable and inexpensive hydrated-metal inorganic salts and environmentally friendly solvents such as water and ethanol. The synthesis involves the dissolution of the metal salt in a solvent followed by the addition of a proton scavenger, which induces gel formation in a timely manner. Both critical point (supercritical extraction) and atmospheric (low temperature evaporation) drying may be employed to produce monolithic aerogels and xerogels, respectively. Using this method synthesis of metal-oxide nanostructured materials have been carried out using inorganic salts, such as of Fe 3+ , Cr 3+ , Al 3+ , Ga 3+ , In 3+ , Hf 4+ , Sn 4+ , Zr 4+ , Nb 5+ , W 6+ , Pr 3+ , Er 3+ , Nd 3+ , Ce 3+ , U 3+ and Y 3+ . The process is general and nanostructured metal-oxides from the following elements of the periodic table can be made: Groups 2 through 13, part of Group 14 (germanium, tin, lead), part of Group 15 (antimony, bismuth), part of Group 16 (polonium), and the lanthanides and actinides. The sol-gel processing allows for the addition of insoluble materials (e.g., metals or polymers) to the viscous sol, just before gelation, to produce a uniformly distributed nanocomposites upon gelation. As an example, energetic nanocomposites of Fe x O y gel with distributed Al metal are readily made. The compositions are stable, safe, and can be readily ignited to thermitic reaction.

专利号:US-2003045743-A1
优先权日:2001-06-27
标 题 :Chiral resolution method for producing compounds useful in the synthesis of taxanes