CAS: 114-07-8; Erythromycin

上下游产品

9-deoxo-9-iminoerythromycin A 9-N,11-O-benzylidene-9-deoxo-9-iminoerythromycin A 45H74N2O12C45H74N2O12 44H71ClN2O12C44H71ClN2O12R)-14t-ethyl-6t-[O-(4-carboxy-butyryl)-3-dimethylamino-β-D-xylo-3,4,6-trideoxy-hexopyranosyloxy]-4t-(3,O3-dimethyl-α-L-ribo-2,6-dideoxy-hexopyranosyloxy)-7c,12t,13c-trihydroxy-3r,5(3R)-14t-ethyl-6t-[O-(4-carboxy-butyryl)-3-dimethylamino-β-D-xylo-3,4,6-trideoxy-hexopyranosyloxy]-4t-(3,O3-dimethyl-α-L-ribo-2,6-dideoxy-hexopyranosyloxy)-7c,12t,13c-trihydroxy-3r,5 O''-(Furan-2-carbonyl)-erythromycinO''-(Furan-2-carbonyl)-erythromycin O''-(2-Carboxy-benzoyl)-erythromycinO''-(2-Carboxy-benzoyl)-erythromycin O''-prop-2-ynyloxycarbonyl-erythromycinO''-prop-2-ynyloxycarbonyl-erythromycin

在 甲醇,N-氯代丁二酰亚胺,Sodium Amalgam,水,Silver Fluoride体系中,用 吡啶,六甲基磷酰三胺 用作溶剂,化学反应生成红霉素
参考文献:红霉素的不对称全合成.3. 红霉素的全合成
标题:红霉素的不对称全合成.3. 红霉素的全合成
摘要:在之前的论文中,我们描述了光学活性形式的关键内酯中间体 1A 的制备.在本文中,我们报告了来自 La 的红霉素 (2) 的合成.从本质上讲,这种转化包括用 L-Cladinose 和 D-Desosamine 对 La 的合适衍生物进行糖苷化,并产生 C-9 酮官能团.
Doi:10.1021/ja00401A051

专利信息

专利号:WO-2025175670-A1
优先权日:2024-02-22
标 题:Engineered cell for heterologous synthesis of erythromycin, synthesis method and use
发明人：WANG YONG; FENG ZHANGUANG
权利人:CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES
摘要:Provided are an engineered cell for heterologous synthesis of erythromycin, a synthesis method and the use. An essential gene for heterologous synthesis of erythromycin is integrated into the chromosome of a prokaryotic cell; and on the basis of the gene, the yield of erythromycin A is greatly improved by means of targeted knockout of a set of genes. A new way is provided for the breeding of high-yield Escherichia coli strains for erythromycin production and industrial application thereof.

专利号:US-10920229-B2
优先权日:2014-07-16
标 题:Method for improving heterologous synthesis of Escherichia coli into polyketides and use of same
发明人：WANG YONG; XIONG ZHIQIANG; SONG SHUJIE; LIU QIAOXIA; WANG JIANFENG
权利人:SHANGHAI INST BIOLOGICAL SCIENCES CAS; CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES
摘要:The present invention relates to a method for improving the heterologous synthesis of a polyketide by E. coli and use thereof. The yield of the polyketide heterologously synthesized by E. coli is significantly increased by attenuating the expression of seventy-two genes, such as sucC and talB, in a host strain, wherein the highest yield increase rate can reach 60% or more. Currently, erythromycin is the most clear model compound in the study on the biosynthesis of polyketids. The production strain of the present invention enables massive accumulation of 6-deoxyerythronolide (6-dEB), an erythromycin precursor, in the fermentation process, laying the foundation for the industrial production of the heterologous synthesis of erythromycin by E. coli.

专利号:US-4751312-A
优先权日:1984-07-20
标 题:Process and intermediates for the synthesis of diastereomeric compounds
发明人：GASTEIGER JOHANN; KAUFMANN KARLHEINZ; MENGEL RUDOLF
权利人:BAYER AG
摘要:A new process for the controlled synthesis of the two diasteromeric forms of triazolyl-O,N-acetals of the formula (I) in which R represents optionally substituted phenyl, optionally substituted phenoxy, optionally substituted alkoxy, optionally substituted alkoxy, optionally substituted alkylthio, alkylcarbonyl, nitro or halogen and n represents an integer from 0 to 5, with the proviso that R can represent identical or different radicals, if n represents an integer from 2 to 5. New trans-substituted oxiranes and their use as intermediates for the synthesis of compounds of the formula (I).

专利号:US-4870199-A
优先权日:1986-04-30
标题 :Processes for the synthesis of diprotected R[R*,S*]-3,5-dihydroxy-6-oxohexanoate esters
发明人：CHEN KAU-MING; HARDTMANN GOETZ E; KAPA PRASAD K; LEE GEORGE T; LINDER JEROME; WATTANASIN SOMPONG
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Process for the synthesis of compounds of the formula in R[R*,S*] enantiomeric form, wherein each P1 is independently an hydroxy group-protecting group, and R2z is C1-4alkyl, benzyl or allyl, comprising, as a key step when R2z is R2x, the reaction of the compound of the formula in (S) enantiomeric form with a compound of the formula Mg &cir& +2 ((-)OOC-CH2-COOR2x)2 to obtain a compound of the formula in (S) enantiomeric form, and, as a key step when R2z is R2y, the reaction of a compound of the formula in (S) enantioimeric form with a compound of the formula Li(+)(-)CH2-COOR2y to obtain a compound of the formula in (S) enantiomeric form, wherein R2x is primary or secondary C1-4alkyl, benzyl or allyl, R2y is C1-4alkyl not containing an asymmetric carbon atom, and R3' is methyl or ethyl, processes for the synthesis of compounds of the formula comprising reacting a compound of the formula with the reaction product of a strong base and a compound of the formula optionally followed by, when R2z is allyl, cleavage of the allyl and P1 groups to obtain the corresponding compound of the formula wherein each R7 is methyl or ethyl, R is as defined in the specification, and each P1 independently and R2z are as defined above, and the compounds of the formula wherein R and each R7 are as defined above.

专利号:US-4739073-A
优先权日:1983-11-04
标题:Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
发明人：KATHAWALA FAIZULLA G
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula wherein one of R and Ro is and the other is primary or secondary C1-6alkyl not containing an asymmetric carbon atom, C3-6cycloalkyl or phenyl(CH2)m-, wherein R4 is hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, C1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R5 is hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R5a is hydrogen, C1-2alkyl, C1-2alkoxy, fluoro or chloro, and m is 1, 2 or 3, with the provisos that both R5 and R5a must be hydrogen when R4 is hydrogen, R5a must be hydrogen when R5 is hydrogen, not more than one of R4 and R5 is trifluoromethyl, not more than one of R4 and R5 is phenoxy, and not more than one of R4 and R5 is benzyloxy, R2 is hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, C3-6cycloalkyl, C1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R3 is hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, with the provisos that R3 must be hydrogen when R2 is hydrogen, not more than one of R2 and R3 is trifluoromethyl, not more than one of R2 and R3 is phenoxy, and not more than one of R2 and R3 is benzyloxy, X is -(CH2)n- or -CH=CH-, wherein n is 0, 1, 2 or 3, and Z is wherein R6 is hydrogen or C1-3alkyl, and R7 is hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, benzyl or M, wherein M is a pharmaceutically acceptable cation, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level, and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

专利号:US-4743694-A
优先权日:1986-04-11
标 题 :Diastereocontrolled synthesis of 2-amino alcohols
发明人：CLAREMON DAVID A
权利人:MERCEK & CO INC
摘要:The addition of organolithium to dimethylhydrazones of certain ethers of a-hydroxyaldehydes results in the synthesis of threo- or erythro- intermediates readily convertible to threo- or erythro-2-amino alcohols.