专利号:US-6525061-B1 优先权日:1999-11-16 标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives 发明人:GOPALSAMY ARIAMALA; YANG HUI Y 权利人:WYETH CORP 摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.
专利号:US-6274383-B1 优先权日:1997-12-15 标题:Methods for synthesizing libraries of dihydro-quinazolinones 发明人:GAO YUN 权利人:SEPRACOR INC 摘要:Synthetic methods for solution and solid-phase synthesis of combinatorial libraries of dihydro-quinazolinones, including synthesis of 2,3-dihydro-3-alkoxy-4(1H)-quinazolinones or 2,3-dihydro-3-hydroxy-4(1H)-quinazolinones via the Lewis-acid catalyzed reaction of an appropriate 2-aminobenzamide with an aldehyde at ambient temperature performed on a solid support or in solution.
专利号:US-6187923-B1 优先权日:1998-11-09 标题 :Process for the synthesis of quinazolinones 发明人:DENER JEFFREY MARK; LY CUONG QUOC 权利人:AXYS ADVANCED TECHNOLOGIES INC 摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B:
专利号:US-4633009-A 优先权日:1985-06-18 标题:Synthesis of methyl N-methylanthranilate 发明人:LERNER DAVID I 权利人:FRIZSCHE DODGE & OLCOTT INC 摘要:Methyl N-methylanthranilate is prepared by reductive alkylation of methylanthranilate with formaldehyde and hydrogen in the presence of a hydrogenation catalyst and an acid catalyst.
专利号:US-8648035-B2 优先权日:2007-08-17 标题 :Identification and use of peptide inhibitors of protein synthesis 发明人:LLANO-SOTELO BEATRIZ; MANKIN ALEXANDER S; KLEPACKI DOROTA 权利人:LLANO-SOTELO BEATRIZ; MANKIN ALEXANDER S; KLEPACKI DOROTA; UNIV ILLINOIS 摘要:The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit.
专利号:US-11440892-B2 优先权日:2019-07-03 标 题 :Substituted dihydrobenzoxazinones, dihydroquinolones, and methods of their use and synthesis 发明人:SCHEIDT KARL A; LEE ANSOO 权利人:UNIV NORTHWESTERN 摘要:Disclosed are dihydrobenzoxazinone compounds, dihydroquinolone compounds, and methods of their synthesis. The disclosed compounds may be prepared by reacting a benzoxazinedione compound and a ketone compound in the presence of an N-heterocyclic carbine (NHC) catalyst to perform a NHC-catalyzed decarboxylative cycloaddition. The disclosed compounds may be utilized to treat diseases and disorders associated with the biological activity of dihydrobenzoxazinone compounds and dihydroquinolone compounds.
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