CAS: 10328-92-4; 1-Methyl-1H-Benzo[d][1,3]Oxazine-2,4-Dione

该化合物是化学化合物,其特点是由异氧酸衍生的碳氢化物功能组,一般是白色和白外固体,以反应作用著称,特别是电热反应.该化合物在有机溶剂中可溶解,在各种化学合成中有用.N-甲基乙酸酐经常用于生产药品和农用化学品,作为合成较复杂的分子的中间体.其结构包括氮原子的甲基组,可影响其再活动及与其他化学物种的相互作用.与许多亚水化物一样,它与水一起形成相应的碳酸,它也可能表现出刺激性,需要在实验室环境中进行仔细处理.总的来说,N-甲基乙酸酐是有机合成中的一种有价值的化合物,特别是在生物活性化合物的开发中.

结构式图片

相似化合物

14529-12-5 35710-05-5 59824-69-0

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上下游产品

CAS号118-48-9 靛红酸酐 | CAS号74-88-4 碘甲烷 | CAS号201230-82-2 carbon monoxide | CAS号100-61-8 N-甲基苯胺 | CAS号77-78-1 硫酸二甲酯 | CAS号118-92-3 邻氨基苯甲酸 | CAS号2058-74-4 1-甲基靛红 | CAS号119-68-6 2-(甲氨基)苯甲酸 | CAS号79-22-1 氯甲酸甲酯 | CAS号541-41-3 氯甲酸乙酯 | CAS号108325-70-8 2-(hydroxymethy... | CAS号1104466-39-8 4-Hydroxy-1-met... | CAS号35472-56-1 2-(甲基氨基)苯甲酸乙酯 | CAS号81235-51-0 1-methyl-2,2-di... | CAS号19050-63-6 2-METHYLAMINO-N... | CAS号21097-36-9 1-methyl-3-phen... | CAS号91-22-5 喹啉 | CAS号719-54-0 N-甲基吖啶酮 | CAS号84088-42-6 利诺安 | CAS号85-91-6 N-甲基邻氨基苯甲酸甲酯

合成工艺路线路线简述

    📜N-甲基蒽置于potassium Carbonate体系中,用 水 用作溶剂,化学反应 0.67H,反应生成1-甲基苯唑
    参考文献:Rutaceous Constituents-13
    标题:Rutaceous Constituents-13
    摘要:
    Doi:10.1016/s0040-4020(01)97737-3

    专利信息


    专利号:US-6525061-B1
    优先权日:1999-11-16
    标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives
    发明人:GOPALSAMY ARIAMALA; YANG HUI Y
    权利人:WYETH CORP
    摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

    专利号:US-6274383-B1
    优先权日:1997-12-15
    标题:Methods for synthesizing libraries of dihydro-quinazolinones
    发明人:GAO YUN
    权利人:SEPRACOR INC
    摘要:Synthetic methods for solution and solid-phase synthesis of combinatorial libraries of dihydro-quinazolinones, including synthesis of 2,3-dihydro-3-alkoxy-4(1H)-quinazolinones or 2,3-dihydro-3-hydroxy-4(1H)-quinazolinones via the Lewis-acid catalyzed reaction of an appropriate 2-aminobenzamide with an aldehyde at ambient temperature performed on a solid support or in solution.

    专利号:US-6187923-B1
    优先权日:1998-11-09
    标题 :Process for the synthesis of quinazolinones
    发明人:DENER JEFFREY MARK; LY CUONG QUOC
    权利人:AXYS ADVANCED TECHNOLOGIES INC
    摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B:

    专利号:US-4633009-A
    优先权日:1985-06-18
    标题:Synthesis of methyl N-methylanthranilate
    发明人:LERNER DAVID I
    权利人:FRIZSCHE DODGE & OLCOTT INC
    摘要:Methyl N-methylanthranilate is prepared by reductive alkylation of methylanthranilate with formaldehyde and hydrogen in the presence of a hydrogenation catalyst and an acid catalyst.

    专利号:US-8648035-B2
    优先权日:2007-08-17
    标题 :Identification and use of peptide inhibitors of protein synthesis
    发明人:LLANO-SOTELO BEATRIZ; MANKIN ALEXANDER S; KLEPACKI DOROTA
    权利人:LLANO-SOTELO BEATRIZ; MANKIN ALEXANDER S; KLEPACKI DOROTA; UNIV ILLINOIS
    摘要:The present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an interaction at a stem-loop H18 in 16S rRNA of a 30S ribosomal subunit. Screening methods for peptides are disclosed, in addition to methods of determining the affinity of a test compound for a ribosomal subunit.

    专利号:US-11440892-B2
    优先权日:2019-07-03
    标 题 :Substituted dihydrobenzoxazinones, dihydroquinolones, and methods of their use and synthesis
    发明人:SCHEIDT KARL A; LEE ANSOO
    权利人:UNIV NORTHWESTERN
    摘要:Disclosed are dihydrobenzoxazinone compounds, dihydroquinolone compounds, and methods of their synthesis. The disclosed compounds may be prepared by reacting a benzoxazinedione compound and a ketone compound in the presence of an N-heterocyclic carbine (NHC) catalyst to perform a NHC-catalyzed decarboxylative cycloaddition. The disclosed compounds may be utilized to treat diseases and disorders associated with the biological activity of dihydrobenzoxazinone compounds and dihydroquinolone compounds.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Baes R, Charlier D, Peeters E. Determination of RNA Structure with In Vitro SHAPE Experiments. Methods Mol Biol. 2022;2516:259-290. doi: 10.1007/978-1-0716-2413-5_14. 408(16):4413-24. doi: 10.1007/s00216-016-9546-4. Epub 2016 Apr 23. 1597(2):229-43. doi: 10.1016/s0167-4838(02)00265-0. 63(2):144-59. doi: 10.1016/j.ymeth.2013.04.023. Epub 2013 May 23.
    5: Lin C, Poyer S, Zargarian L, Salpin JY, Fossé P, Mauffret O, Xie J. Identification of acylation products in SHAPE chemistry. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2506-2509. doi: 10.1016/j.bmcl.2017.03.096. Epub 2017 Apr 1. 19(4):432-8. doi: 10.1007/BF02471624. 123(10):e2511535123. doi: 10.1073/pnas.2511535123. Epub 2026 Mar 4.
    8: Turner KB, Yi-Brunozzi HY, Brinson RG, Marino JP, Fabris D, Le Grice SF. SHAMS: combining chemical modification of RNA with mass spectrometry to examine polypurine tract-containing RNA/DNA hybrids. RNA. 2009 Aug;15(8):1605-13. doi: 10.1261/rna.1615409. Epub 2009 Jun 17.

    合成参考文献


    摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 349.
    摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 350.
    摘要:Camp, J. E., Science of Synthesis Knowledge Updates, (2012) 1, 314.
    摘要:Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 164.
    摘要:Coldham, I.; Sheikh, N. S., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 2, 73.
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