CAS: 90905-32-1; 2-Methoxypyrimidine-5-Carbaldehyde
该化合物是一种多用途的七环甲醚,用作有机合成和药物研究的关键中间体.其亚丁基,与一个甲氧基组和甲代丁胺胺结合发挥作用,能够进行选择性的修改,使其对构建复杂的分子具有价值.该化合物在凝聚和核生殖反应中表现出高度的回反应性,有利于生物活性化合物的合成,包括农业化学品和药物候选者.其明确界定的结构和稳定性确保了合成应用的一贯性.甲代苯基为进一步衍生提供了方便的处理方法,提高了其在医药化学和物质科学中的效用.
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- 产品信息参考
; - InChIKey: MERUNNHMVZFFRE-UHFFFAOYSA-N
- InChI=1S/C6H6N2O2/c1-10-6-7-2-5(4-9)3-8-6/h2-4H,1H3
- 计算化学: 氢键受体数4.0氢键供体数0.0可旋转键数2.0
相似化合物
38373-47-6 1158735-09-1 38373-46-5物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate O-methylisourea hemisulfate 2-methyl-isourea o-methylisourea hydr°Chloride 2-methoxy-5-vinylpyrimidine 2-benzyloxycarbonylamino-3-(2-methoxy-pyrimidin-5-yl)-acrylic acid methyl ester 5-((2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)methyl)-3-(2-methoxypyrimidin-5-yl)isoxazole 2-hydroxypyrimidine-5-carbaldehyde合成工艺路线路线简述
- 14874-70-5 + 45084-94-4 + 2440-60-0 = 90905-32-1
反应条件:1.1 Reagents: Sodium Ethoxide Solvents: Ethanol; Rt; 3 H,Reflux
标题:Nonpeptide αvβ3 Antagonists. Part 11: Discovery And Preclinical Evaluation Of Potent αvβ3 Antagonists For The Prevention And Treatment Of Osteoporosis
作者:Coleman,Paul J.; Brashear,Karen M.; Askew,Ben C.; Hutchinson,John H.; Mcvean,Carol A.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2004 卷标:47(20) 页码:4829-4837]
45084-94-4 + 14797-73-0 + 2440-60-0 = 90905-32-1
反应条件:1.1 Reagents: Sodium Ethoxide,Sodium Carbonate Solvents: Ethanol
标题:An Alternative Preparation Of The 2-Dimethylaminomethylene-1,3-Bis(Dimethylimmonio)Propane Salt From Phosphonoacetic Acids And Some Applications In Heterocyclic Synthesis
作者:Gupton,John T.; Gall,John E.; Riesinger,Steve W.; Smith,Stanton Q.; Bevirt,Kathy M.; Et Al
参考文献:Journal Of Heterocyclic Chemistry 日期:1991 卷标:28(5) 页码:1281-5]
404869-59-6 + 2440-60-0 = 90905-32-1
反应条件:1.1 Reagents: Potassium Bicarbonate Solvents: Isopropyl Acetate,Water; 10 Min,Rt; 40 Min,Rt
标题:Practical Asymmetric Synthesis Of A Non-Peptidic αvβ3 Antagonist
作者:Keen,Stephen P.; Cowden,Cameron J.; Bishop,Brian C.; Brands,Karel M. J.; Davies,Antony J.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(5) 页码:1771-1779
📜2-Dimethylaminomethylene-1,3-Bis(Dimethylimmonio)Propane Bistetrafluoroborate,O-甲基异脲置于sodium Ethanolate,盐酸体系中,用 乙醇,四氢呋喃 作为反应溶剂,以80%的收率获得产物2-甲氧基-5-醛基嘧啶
参考文献:Ragan; Mcdermott; Jones,Synlett,2000,# 8,P. 1172-1174
标题:Ragan; Mcdermott; Jones,Synlett,2000,# 8,P. 1172-1174
海关参考信息
- 2905110000-甲醇
2912110000-甲醛
2909199090-其他醚及其衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7288655-B2
优先权日:2003-03-07
标 题 :α v integrin receptor antagonists
发明人：BISHOP BRIAN CHRISTOPHER; BRANDS KAREL MARIE JOSEPH; COTTRELL IAN FRANK; COWDEN CAMERON JOHN; DAVIES ANTONY JOHN; KEEN STEPHEN PHILIP; LIEBERMAN DAVID ROSS; STEWART GAVIN WILLIAM
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds. The compounds of formula (A) are useful as ανβ3 receptor antagonists
专利号:US-6410526-B1
优先权日:1999-06-02
标题 :αv integrin receptor antagonists
发明人：DUGGAN MARK E; HARTMAN GEORGE D; MEISSNER ROBERT S; PERKINS JAMES J
权利人:MERCK & CO INC
摘要:The present invention relates to novel nonanoic acid derivatives, their synthesis, and their use as alphav integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphavbeta3 and alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.
专利号:US-7056909-B2
优先权日:2000-07-26
标题 :Alpha v integrin receptor antagonists
发明人：WANG JIABING
权利人:MERCK & CO INC
摘要:The present invention relates to novel chain-fluorinated alkanoic acid derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.
专利号:US-7153862-B2
优先权日:2000-01-24
标 题 :αv integrin receptor antagonists
发明人：ASKEW BEN C; BRESLIN MICHAEL J; DUGGAN MARK E; HUTCHINSON JOHN H; MEISSNER ROBERT S; PERKINS JAMES J; STEELE THOMAS G; PATANE MICHAEL A
权利人:MERCK & CO INC
摘要:The present invention relates to novel alkanoic acid derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 161.
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