CAS: 872-93-5; 3-Methyltetrahydrothiophene 1,1-Dioxide
该化合物是一个具有独特结构的全氟辛烷磺酸化合物,其中包括一个附于饱和碳链的磺酰胺组(SO2欧元),在室内温度下对黄色的黄色液体来说是无色的,具有相对较高的沸点和低的挥发性,因此适合有机合成和溶剂的各种应用,甲基组的存在增加了其极分性,使它得以溶解广泛的极性和非极性物质. 3-甲基乙基硫酸酯因其热稳定性和对氧化的耐受性而著称,使其在化学反应中,特别是在制药和石化工业中,成为有价值的溶剂.此外,与其他有机溶剂相比,它具有相对较低的毒性特征,这有助于其在工业应用中的吸引力.其独特的特性也使它可以用于绿色化学,其重点是减少环境影响,同时保持化学工艺的效率.
- 英文名称3-Methyltetrahydrothiophene 1,1-Dioxide
- 中文名称3-甲基环丁砜
- IUPAC名称3-methyltetrahydrothiophene 1,1-dioxide
- 其它别名3-甲基四氢噻吩1,1-二氧化物; 3-Methyltetrahydrothiophene 1,1-Dioxide
- CAS编号872-93-5
- MFCD编号:MFCD00005487
- EINECS号:212-833-9
- 分子式:C5H10O2S分子量:134.2
- 产品CID: 1879196
- 产品分类有机原料→分子砌块→脂肪杂环类化合物→其它脂肪杂环类化合物
相似化合物
126-33-0 2138399-45-6 17389-09-2物理性质
MSDS等安全信息
欧盟法规
REACH注册ECHA物质REACH预注册上下游产品
CAS号321979-37-7 3-bromomethylte... | CAS号314056-83-2 ((but-3-en-1-yl... | CAS号55881-94-2 2-methylidenebu... | CAS号720719-20-0 3-hydroxymethyl... | CAS号720719-27-7 3-phenylselenyl... | CAS号720719-21-1 3-bromomethylte... | CAS号17236-20-3 3-(hydroxymethy...合成工艺路线路线简述
- 4740-00-5 = 872-93-5
反应条件:1.1 Reagents: Hydrogen Peroxide
标题:Method For The Preparation Of 2- And 3-Alkyl(Cycloalkyl Or Phenyl)Thiophanes
作者:Volynskii,N. P.; Et Al
参考文献:Izvestiya Akademii Nauk Sssr 日期:1979 卷标:(5) 页码:1080-5]
720719-27-7 = 872-93-5
反应条件:1.1 Solvents: Benzene; Reflux1.2 Reagents: Tributylstannane Catalysts: Azobisisobutyronitrile Solvents: Benzene; 30 Min,Reflux; 60 Min,Reflux1.3 Reagents: Carbon Tetrachloride
标题:The Regiochemistry Of Cyclization Of α-Sulfenyl-,α-Sulfinyl-,And α-Sulfonyl-5-Hexenyl Radicals: Procedures Leading To Regioselective Syntheses Of Cyclic Sulfones And Sulfoxides
作者:Della,Ernest W.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(11) 页码:3824-3835]
23974-72-3 + 720719-20-0 = 872-93-5
反应条件:1.1 Reagents: Sodium Periodate Solvents: Acetone,Water; 0 °C; 2 H,0 °C -> Rt1.2 Reagents: Triethylamine,Methanesulfonyl Chloride; 3 H,Rt1.3 Solvents: Diethyl Ether; Rt1.4 Solvents: Ethanol; Overnight,Rt2.1 Solvents: Benzene; Reflux2.2 Reagents: Tributylstannane Catalysts: Azobisisobutyronitrile Solvents: Benzene; 30 Min,Reflux; 60 Min,Reflux2.3 Reagents: Carbon Tetrachloride
标题:The Regiochemistry Of Cyclization Of α-Sulfenyl-,α-Sulfinyl-,And α-Sulfonyl-5-Hexenyl Radicals: Procedures Leading To Regioselective Syntheses Of Cyclic Sulfones And Sulfoxides
作者:Della,Ernest W.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(11) 页码:3824-3835]
148420-02-4 = 872-93-5
反应条件:1.1 Reagents: Disodium Sulfide Solvents: Ethanol,Water2.1 Reagents: (Dimethyl Sulfide)Trihydroboron; 0 °C; 1 H,Rt; Rt -> 0 °C2.2 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 0 °C -> Rt; 2 H,Rt3.1 Reagents: Sodium Periodate Solvents: Acetone,Water; 0 °C; 2 H,0 °C -> Rt3.2 Reagents: Triethylamine,Methanesulfonyl Chloride; 3 H,Rt3.3 Solvents: Diethyl Ether; Rt3.4 Solvents: Ethanol; Overnight,Rt4.1 Solvents: Benzene; Reflux4.2 Reagents: Tributylstannane Catalysts: Azobisisobutyronitrile Solvents: Benzene; 30 Min,Reflux; 60 Min,Reflux4.3 Reagents: Carbon Tetrachloride
标题:The Regiochemistry Of Cyclization Of α-Sulfenyl-,α-Sulfinyl-,And α-Sulfonyl-5-Hexenyl Radicals: Procedures Leading To Regioselective Syntheses Of Cyclic Sulfones And Sulfoxides
作者:Della,Ernest W.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(11) 页码:3824-3835]
321979-37-7 = 872-93-5
反应条件:1.1 Reagents: Tributylstannane Catalysts: Azobisisobutyronitrile Solvents: Benzene; 5 Min,Reflux; 60 Min,Reflux1.2 Reagents: Carbon Tetrachloride
标题:The Regiochemistry Of Cyclization Of α-Sulfenyl-,α-Sulfinyl-,And α-Sulfonyl-5-Hexenyl Radicals: Procedures Leading To Regioselective Syntheses Of Cyclic Sulfones And Sulfoxides
作者:Della,Ernest W.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(11) 页码:3824-3835]
= 872-93-5
反应条件:1.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: Dichloromethane; 0 °C; Overnight,0 °C1.2 Reagents: Methyl Iodide Solvents: Diethyl Ether2.1 Reagents: Tributylstannane Catalysts: Azobisisobutyronitrile Solvents: Benzene; 5 Min,Reflux; 60 Min,Reflux2.2 Reagents: Carbon Tetrachloride
标题:The Regiochemistry Of Cyclization Of α-Sulfenyl-,α-Sulfinyl-,And α-Sulfonyl-5-Hexenyl Radicals: Procedures Leading To Regioselective Syntheses Of Cyclic Sulfones And Sulfoxides
作者:Della,Ernest W.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(11) 页码:3824-3835]
54462-66-7 = 872-93-5
反应条件:1.1 Reagents: Disodium Sulfide2.1 Reagents: Hydrogen Peroxide
标题:Method For The Preparation Of 2- And 3-Alkyl(Cycloalkyl Or Phenyl)Thiophanes
作者:Volynskii,N. P.; Et Al
参考文献:Izvestiya Akademii Nauk Sssr 日期:1979 卷标:(5) 页码:1080-5]
143435-56-7 = 872-93-5
反应条件:1.1 Reagents: (Dimethyl Sulfide)Trihydroboron; 0 °C; 1 H,Rt; Rt -> 0 °C1.2 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Water; 0 °C -> Rt; 2 H,Rt2.1 Reagents: Sodium Periodate Solvents: Acetone,Water; 0 °C; 2 H,0 °C -> Rt2.2 Reagents: Triethylamine,Methanesulfonyl Chloride; 3 H,Rt2.3 Solvents: Diethyl Ether; Rt2.4 Solvents: Ethanol; Overnight,Rt3.1 Solvents: Benzene; Reflux3.2 Reagents: Tributylstannane Catalysts: Azobisisobutyronitrile Solvents: Benzene; 30 Min,Reflux; 60 Min,Reflux3.3 Reagents: Carbon Tetrachloride
标题:The Regiochemistry Of Cyclization Of α-Sulfenyl-,α-Sulfinyl-,And α-Sulfonyl-5-Hexenyl Radicals: Procedures Leading To Regioselective Syntheses Of Cyclic Sulfones And Sulfoxides
作者:Della,Ernest W.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(11) 页码:3824-3835]
71052-94-3 = 872-93-5
反应条件:1.1 Reagents: Phosphorus Tribromide,Hydrogen Bromide2.1 Reagents: Disodium Sulfide3.1 Reagents: Hydrogen Peroxide
标题:Method For The Preparation Of 2- And 3-Alkyl(Cycloalkyl Or Phenyl)Thiophanes
作者:Volynskii,N. P.; Et Al
参考文献:Izvestiya Akademii Nauk Sssr 日期:1979 卷标:(5) 页码:1080-5]
720719-20-0 = 872-93-5
反应条件:1.1 Reagents: Sodium Periodate Solvents: Methanol,Water; 0 °C; 2 H,0 °C -> Rt2.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: Dichloromethane; 0 °C; Overnight,0 °C2.2 Reagents: Methyl Iodide Solvents: Diethyl Ether3.1 Reagents: Tributylstannane Catalysts: Azobisisobutyronitrile Solvents: Benzene; 5 Min,Reflux; 60 Min,Reflux3.2 Reagents: Carbon Tetrachloride
标题:The Regiochemistry Of Cyclization Of α-Sulfenyl-,α-Sulfinyl-,And α-Sulfonyl-5-Hexenyl Radicals: Procedures Leading To Regioselective Syntheses Of Cyclic Sulfones And Sulfoxides
作者:Della,Ernest W.; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(11) 页码:3824-3835]
3565-66-0 = 872-93-5
反应条件:1.1 -2.1 Reagents: Phosphorus Tribromide,Hydrogen Bromide3.1 Reagents: Disodium Sulfide4.1 Reagents: Hydrogen Peroxide
标题:Method For The Preparation Of 2- And 3-Alkyl(Cycloalkyl Or Phenyl)Thiophanes
作者:Volynskii,N. P.; Et Al
参考文献:Izvestiya Akademii Nauk Sssr 日期:1979 卷标:(5) 页码:1080-5]
= 872-93-5
反应条件:1.1 -2.1 -3.1 Reagents: Phosphorus Tribromide,Hydrogen Bromide4.1 Reagents: Disodium Sulfide5.1 Reagents: Hydrogen Peroxide
标题:Method For The Preparation Of 2- And 3-Alkyl(Cycloalkyl Or Phenyl)Thiophanes
作者:Volynskii,N. P.; Et Al
参考文献:Izvestiya Akademii Nauk Sssr 日期:1979 卷标:(5) 页码:1080-5]
314056-83-2 = 872-93-5 + 4988-33-4 + 273754-86-2
反应条件:1.1 Reagents: Tributyltin Oxide1.2 Reagents: Tributylstannane
标题:Ring Closure Of 2-Thia- And 2-Sulfonyl-5-Hexenyl Radicals
作者:Della,Ernest W.; Et Al
参考文献:Tetrahedron Letters 日期:2000 卷标:41(41) 页码:7987-7990
📜2-甲基-1,4-丁二醇置于sodium Sulfide,间氯过氧苯甲酸体系中,化学反应生成 3-甲基环丁砜
参考文献:α-亚磺酰基-,α-亚磺酰基-和α-磺酰基-5-己烯基自由基环化的区域化学:导致环砜和亚砜区域选择性合成的方法
标题:α-亚磺酰基-,α-亚磺酰基-和α-磺酰基-5-己烯基自由基环化的区域化学:导致环砜和亚砜区域选择性合成的方法
摘要:对α-亚磺酰基-,α-亚磺酰基-和α-磺酰基-5-己烯基和5-甲基-5-己烯基的环化研究表明,该基团的闭环方式具有独特的反差.在5-己烯基的情况下,亚磺酰基取代的物质相对于其类似物显示出意外的区域选择性.因此,虽然α-S-和α-So 2-5-己烯基的基团,得到6-可测量和增加数量内的产品,以高选择性(95.5:4.5)的α-亚磺酰物种经由环化的5-外切模式.相比之下,发现5-甲基-5-己烯基的闭环基本上给出了6-内所有情况下的产品.现在,对于6-内膜封闭,具有高区域选择性(97.5:2.5)的是α-磺酰基-5-甲基-5-己烯基:该观察值的合成的例证是模型环己基砜的独立合成61高产.已经发现,在所有情况下,在所采用的条件下均不可逆地发生闭环.
DOI:10.1021/jo0497306
海关参考信息
- 2930909099-其他有机硫化合物
2904990090-其他烃的磺化、硝化、亚硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.
专利号:WO-2020208409-A1
优先权日:2019-04-10
标 题 :Improved processes for the preparation of peptide intermediates/modifiers
发明人：BUDHDEV DR RAJEEV REHANI; NARIYAM MUNASWAMY SEKHAR; AKULA SWAPNA; KAIPU RAMAKRISHNA REDDY; KOMATI SHRAVAN KUMAR; KARTHIK RAMASWAMY; KOMARAVOLU YAGNA KIRAN KUMAR
权利人:Dr Reddy’s Laboratories Ltd
摘要:The present application relates to improved processes for the preparation of peptide intermediates/modifier compounds of Formula (I) and their use in the synthesis of peptide derivatives. The present application further provides the compound of Formula I with high chemical purity of >98% and chiral purity of >99% and its use to make pharmaceutical peptide like Liraglutide.
专利号:US-8653282-B2
优先权日:2007-10-18
标 题:Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein
发明人：FRUTOS ROGELIO; KRISHNAMURTHY DHILEEPKUMAR; MULDER JASON ALAN; RODRIGUEZ SONIA; SENANAYAKE CHRIS HUGH; TAMPONE THOMAS G
权利人:FRUTOS ROGELIO; KRISHNAMURTHY DHILEEPKUMAR; MULDER JASON ALAN; RODRIGUEZ SONIA; SENANAYAKE CHRIS HUGH; TAMPONE THOMAS G; BOEHRINGER INGELHEIM INT
摘要:The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO 2 , preferably SO, and wherein R A , R 1 , R 2 , R 3 , R 4 and R 5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.
专利号:US-10927095-B2
优先权日:2017-08-14
标 题:Processes for the preparation of Niraparib and intermediates thereof
发明人：LUTHRA PARVEN K; VASOYA SANJAY L; PATIL BHATU T; TANEJA AMIT K; SRIVASTAV NAVEEN C; SINGH RINKU
权利人:TEVA PHARMACEUTICALS INT GMBH
摘要:The present invention relates to novel procedures and novel intermediates useful in the synthesis of Niraparib or any salt thereof.
专利号:US-4311862-A
优先权日:1979-09-04
标 题:Preparation of unsaturated ethers
发明人：DRENT EIT
权利人:SHELL OIL CO
摘要:Process for the preparation of olefinically unsaturated ethers by reacting a conjugated diene and a lower alkanol with the aid of an acidic catalyst in the presence of a non-basic aprotic polar solvent. The olefinically unsaturated ethers are of interest as solvents and gasoline additives and can also be used as starting materials for e.g. the synthesis of ketones.
专利号:WO-2023214577-A1
优先权日:2022-05-02
标 题 :Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:The present invention addresses the problem of a desired elongation reaction not progressing as a result of a 6-membered cyclic amidine skeleton structure and a diketopiperazine formed when removing an N-terminated protective group during peptide synthesis. The inventors have discovered that it is possible to solve said problem during peptide production by treating a peptide protected by an N-terminated amino group in a protective group having an Fmoc skeleton by using a base which has a pKa of 23 or higher in an acetonitrile of a conjugate acid in a specific solvent, and next, performing peptide chain elongation.
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1186/s42834-023-00166-x
摘要:Wang C, Liang C, Liu Y, Yang C. Sulfolane degrading bacteria from petrochemical plant: activated sludge enrichment, isolation and characterization. Sustain Environ Res. 2023 Feb 15;33(1). doi: 10.1186/s42834-023-00166-x.
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