CAS: 774582-60-4; 7-(Benzyloxy)-5-Bromo-2-Methyl-1H-Benzo[d]Imidazole
该化合物是一种溴化联苯胺衍生物,在2位置为一组,在4位置为一组,在4位置为一甲基,在苯氧基替代成分;该化合物是有机合成的多种中间体,特别是在制药和农用化学品开发方面;该溴组为进一步功能化增强回动性,而苯氧基混合物则有可能选择性地去保护或改变;其硬性苯并基核心有助于稳定性和约束性亲和性,使其在针对生物系统的药用化学中具有价值;该化合物的特点是高纯度和高性能,在交叉组合和热循环反应中具有一贯性.
- 英文名称7-(Benzyloxy)-5-Bromo-2-Methyl-1H-Benzo[d]Imidazole
- 中文名称7-(苯氧基)-5-溴-2-甲基-1h-苯并唑[d]咪唑
- IUPAC名称7-(benzyloxy)-5-bromo-2-methyl-1H-benzo[d]imidazole
- 其它别名1H-Benzimidazole, 6-Bromo-2-Methyl-4-(Phenylmethoxy)-; 4-(Benzyloxy)-6-Bromo-2-Methyl-1H-Benzo[d]Imidazole; 7-(Benzyloxy)-5-Bromo-2-Methyl-1H-Benzo[d]Imidazole; 4-Benzyloxy-6-Bromo-2-Methyl-1H-Benzoimidazole; 1H-Benzimidazole, 5-Bromo-2-Methyl-7-(Phenylmethoxy)-; 6-Bromo-2-Methyl-4-Phenylmethoxy-1H-Benzimidazole; 7-(Benzyloxy)-5-Bromo-2-Methylbenzimidazole; 6-Bromo-2-Methyl-4-[(Phenylmethyl)Oxy]-1H-Benzimidazole
- CAS编号774582-60-4
- MFCD编号:MFCD26391173
- 分子式:C15H13BrN2O分子量:317.19
- 产品CID: 1768634
- 产品分类有机原料→分子砌块→芳杂环类化合物→苯并咪唑类化合物
相似化合物
942195-83-7 2445053-90-5 116345-20-1上下游产品
N-[4-bromo-2-nitro-6-(benzyloxy)phenyl]acetamide 2-(benzyloxy)-4-bromo-6-nitrobenzenamine 2-Amino-3-nitrophenol benzyl chloride 4-(benzyloxy)-6-bromo-2-methyl-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-benzimidazole 6-bromo-2-methyl-1-[(4-methylphenyl)sulfonyl]-4-[(phenylmethyl)oxy]-1H-benzimidazole 4-benzyloxy-6-bromo-1-methoxymethyl-2-methyl-1H-benzimidazole 4-hydroxy-N N,2-trimethyl-1-[(4-methylphenyl)sulfonyl]-1H-benzimidazole-6-carboxamide合成工艺路线路线简述
📜N-[4-溴-2-硝基-6-(苄氧基)苯基]乙酰胺置于铁粉 乙酸乙酯,Brine,水,乙醚,Methanol-Dichloromethane,Magnesium Sulfate体系中,用 溶剂黄146 作为反应溶剂,化学反应 6.0H,以to Afford The Title Compound As A White Solid (54.7 G,53%)的收率获得产物7-(苯氧基)-5-溴-2-甲基-1H-苯并唑[d]咪唑
参考文献:Chromane Substituted Benzimidazole Derivatives
标题:Chromane Substituted Benzimidazole Derivatives
摘要:本发明涉及式(I)的化合物:或其药物可接受的盐,其中a,B,X,R1,R2,R3,R4,R5,R6,R7和r8分别如本文所述或其药物可接受的盐,以及含有这种化合物的组合物和在治疗通过酸泵拮抗活性介导的疾病中使用这种化合物,例如但不限于胃肠疾病,胃食管疾病,胃食管反流病(gerd),消化性溃疡,胃溃疡,十二指肠溃疡,Nsaid引起的溃疡,胃炎,幽门螺杆菌感染,消化不良,功能性消化不良,佐林格-埃里森综合征,非侵蚀性反流性疾病(nerd),内脏疼痛,心灵烦恼,恶心,食管炎,吞咽困难,多口水,气道障碍或哮喘.
海关参考信息
- 2902300000-甲苯
2905110000-甲醇
2906210000-苄醇
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
