CAS: 72420-38-3; 5-Methyl-4-Oxo-5-Phenyl-4,5-Dihydrofuran-2-Carboxylic Acid

上下游产品

Methyl 4,5-Dihydro-5-Methyl-4-Oxo-5-Phenyl-2-Furancarboxylate 72429-82-4

📜苯乙酮置于甲醇,Lithium Hydroxide,正丁基锂,Mercury(II) Perchlorate,Sodium Hydride体系中,用 四氢呋喃,甲醇,正己烷 作为反应溶剂,化学反应生成 阿西弗兰
参考文献:Analogues Of Acifran: Agonists Of The High And Low Affinity Niacin Receptors,Gpr109A And Gpr109B
标题:Analogues Of Acifran: Agonists Of The High And Low Affinity Niacin Receptors,Gpr109A And Gpr109B
摘要:Recently Identified Gpcrs,Gpr109A And Gpr109B,The High And Low Affinity Receptors For Niacin,May Represent Good Targets For The Development Of Hdl Elevating Drugs For The Treatment Of Atherosclerosis. Acifran,An Agonist Of Both Receptors,Has Been Tested In Human Subjects,Yet Until Recently Very Few Analogs Had Been Reported. We Describe A Series Of Acifran Analogs Prepared Using Newly Developed Synthetic Pathways And Evaluated As Agonists For Gpr109A And Gpr109B,Resulting In Identification Of Compounds With Improved Activity At These Receptors.
DOI:10.1021/jm070022X

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-7956214-B2
优先权日:2001-11-02
标题 :Process for the preparation of aniline-derived thyroid receptor ligands
发明人：CHIDAMBARAM RAMAKRISHNAN; KANT JOYDEEP; WEAVER RAYMOND E; YU JURONG; GHOSH ARUN
权利人:KAROBIO AB; BRISTOL MYERS SQUIBB CO
摘要:Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.

专利号:US-10968192-B2
优先权日:2018-09-26
标题:Crystalline solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis
发明人：BEDNARZ MARK STEPHEN; Dai Kuangchu; ECKERT JEFFREY MANNING; LIM NGIAP-KIE; SIROIS LAUREN; WU WENXUE; ZHAO MATTHEW MANGZHU
权利人:LEXICON PHARMACEUTICALS INC
摘要:Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide, and salts, solvates and cocrystals thereof, are disclosed.

专利号:KR-101513003-B1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications