CAS: 69308-37-8; (R)-4-Amino-3-(4-Chlorophenyl)Butanoic Acid

上下游产品

CAS号290366-79-9 (R)-baclofen | CAS号63701-55-3 R-(+)-盐酸巴氯芬 | CAS号245662-60-6 1-[(3S)-3-(4-ch... | CAS号625457-56-9 (R)-ethyl 4-[(t... | CAS号20754-21-6 methyl 3-(4-chl... | CAS号104-88-1 对氯苯甲醛 | CAS号852051-18-4 methyl (R)-(+)-... | CAS号101671-01-6 p-chloro-beta-n...

R(+)-巴氯芬盐酸盐置于sodium Hydroxide体系中,用 水 作为反应溶剂,以91%的收率获得产物(R)-巴氯芬
参考文献:Method Of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid
标题:Method Of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid
摘要:本发明提供了生产化合物(iia)或化合物(iib)的方法,提供了生产化合物(iiia)或化合物(iiib)的方法,提供了生产化合物(va)或其盐或化合物(vb)或其盐的方法,提供了生产化合物(iiia)或化合物(iiib)的方法,此外,还提供了生产化合物(va)或其盐或化合物(vb)或其盐的方法,包括这些生产方法.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:EP-3599246-A1
优先权日:2018-07-25
标题 :Means and methods for synthesizing precursors of y-aminobutyric acid (gaba) analogs
发明人：POELARENDS GERRIT JAN; BIEWENGA LIEUWE; VAN DER MEER JAN-YTZEN; PODDAR HARSHWARDHAN; THANGAVELU SARAVANAN
权利人:UNIV GRONINGEN
摘要:The invention relates to the fields of drug development and biocatalysis, more specifically to a biocatalytic route for asymmetric synthesis of precursors of y-aminobutyric acid (GABA) analogs. Provided is an isolated mutant 4-oxalocrototonate tautomerase (4-OT) enzyme comprising the following mutations (i) leucine at position 8 substituted with a tyrosine (L8Y) or a phenylalanine (L8F); (ii) methionine at position 45 substituted with a tyrosine (M45Y); and (iii) phenylalanine at position 50 substituted with an alanine (F50A), wherein the positions are numbered according to the amino acid sequence of 4-OT ofPseudomonas putida.Also provided is a method for the synthesis of a precursor for the pharmaceutically relevant enantiomer of a GABA analog, comprising (i) providing a y-nitroaldehyde using the 4-OT mutant enzyme, followed by (ii) subjecting the thus obtained y-nitroaldehyde to an enzymatic oxidation reaction catalyzed by an aldehyde dehydrogenase (EC 1.2.1.3).

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

专利号:WO-9941229-A1
优先权日:1998-02-11
标题:Halogenated phenyl alcohol amides (ligands of gabab receptor) having an anticonvulsant activity
发明人：CARVAJAL SANDOVAL GUILLERMO; MEZA TOLEDO SERGIO ENRIQUE
权利人:CARVAJAL SANDOVAL GUILLERMO; MEZA TOLEDO SERGIO ENRIQUE
摘要:New anticonvulsant compounds have been synthesized with a chlorine or fluorine atom in the position para of the phenyl ring. These compounds include DL-2-hydroxy-2-(4'-chlorophenyl)butyramide, DL-2-hydroxy-2-(4'-fluorophenyl)butyramide, DL-3-hydroxy-3-(4'-chlorophenyl)pentanamide, DL-3-hydroxy-3-(4'-fluorophenyl)pentanamide, DL-4-hydroxy-4-(4'-chlorophenyl)hexanamide and DL-4-hydroxy-4-(4'-fluorophenyl)hexanamide. Said compounds have a rather significant anticonvulsant activity against convulsions produced by pentylene tetrazol, as well as unexpected properties in particular a high affinity to the GABAB receptor in addition to a sustained anticonvulsant activity. The invention also relates to methods for the synthesis of halogenated phenyl alcohol amides such as indicated in the examples given in the disclosure.

专利号:EP-2354120-A1
优先权日:2003-08-20
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE
权利人:XENOPORT INC
摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

专利号:WO-2009094569-A2
优先权日:2008-01-25
标 题:Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates