CAS: 61563-36-8; 7,8-Dichloroisoquinoline

相似化合物

73075-59-9 34784-07-1 73075-61-3

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2,3-dichloro-N-(2,2-dimethoxyethyl)benzylidenamine -2,2-dimethoxyethanamineN-(2,3-dichlorophenyl)methylene-2,2-dimethoxyethanamine 2,3-dichlorobenzylaldehyde 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline SKF 64139 hydr°Chloride

📜2,3-二氯苯甲醛置于硫酸体系中,用 苯 作为反应溶剂,化学反应 0.5H,反应生成 7,8-二氯异喹啉
参考文献:Inhibitors Of Phenylethanolamine N-Methyltransferase And Epinephrine Biosynthesis. 1. Chloro-Substituted 1,2,3,4-Tetrahydroisoquinolines
标题:Inhibitors Of Phenylethanolamine N-Methyltransferase And Epinephrine Biosynthesis. 1. Chloro-Substituted 1,2,3,4-Tetrahydroisoquinolines
摘要:In A Search For Inhibitors Of Epinephrine Biosynthesis As Potential Therapeutic Agents,A Series Of 13 Ring-Chlorinated 1,2,3,4-Tetrahydroisoquinolines Was Prepared. These Compounds Were Tested Initially For Their Ability To Inhibit Rabbit Adrenal Phenylethanolamine N-Methyltransferase (Pnmt) In Vitro. Enzyme-Inhibitor Dissociation Constants,Determined For The Six Most Potent Members Of The Series,Indicated The Following Order Of Decreasing Potency: 7,8-Cl2 Greater Than 6,7,8-Cl3 Greater Than 7-Cl Approximately 5,6,7,8-Cl4 Greater Than 5,7,8-Cl3. These Compounds Were Subsequently Examined For Pnmt-Inhibiting Activity In Intact Rats And Mice. 7,8-Dichloro-1,2,3,4-Tetrahydroisoquinoline (13,Sk&f 64139) Was The Most Potent Member Of The Series Both In Vitro And In Vivo And Is Currently Undergoing Clinical Investigation.
DOI:10.1021/jm00179A007