CAS: 599-04-2; (R)-3-Hydroxy-4,4-Dimethyldihydrofuran-2(3H)-One

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CAS号13031-04-4 二氢-4,4-二甲基-2,3-呋喃二酮 | CAS号133094-78-7 3-(tert-butyldi... | CAS号107730-03-0 (R)-2,4-dihydro... | CAS号924-44-7 乙醛酸乙酯 | CAS号78-84-2 异丁醛 | CAS号1112-33-0 泛醇杂质B | CAS号134929-92-3 (2R)-2,4-dihydr... | CAS号28227-36-3 (R)-2-acetoxy-3... | CAS号17968-81-9 (2R)-2,4-dihydr... | CAS号2545-84-8 Ethanesulfonic ... | CAS号81-13-0 D-泛醇 | CAS号79-83-4 泛酸 | CAS号102096-60-6 (R)-α-丙烯酰基氧基-β,... | CAS号157717-58-3 (S)-3-Azido-4,4... | CAS号79-50-5 DL-泛酰内酯 | CAS号18679-90-8 HOPan | CAS号13861-97-7 Γ-二甲基丁内酯 | CAS号7147-30-0 N-[2-[(5-bromop...

2,2-二甲基-3-羟基丙醛置于盐酸体系中,用 甲醇,异丙醚,水 作为反应溶剂,化学反应 2.0H,反应生成 D-(-)-泛酰内酯
参考文献:Calcium Pantothenate. Part 2.1 Optimisation Of Oxynitrilase-Catalysed Asymmetric Hydrocyanation Of 3-Hydroxy-2,2-Dimethylaldehyde: Synthesis Of (R)-Pantolactone
标题:Calcium Pantothenate. Part 2.1 Optimisation Of Oxynitrilase-Catalysed Asymmetric Hydrocyanation Of 3-Hydroxy-2,2-Dimethylaldehyde: Synthesis Of (R)-Pantolactone
摘要:The Synthesis Of (R)-Pantolactone Via Oxynitrilase-Catalysed Asymmetric Hydrocyanation Of 3-Hydroxy-2,2-Dimethylaldehyde Has Been Investigated. (R)-Oxynitrilases From Almonds As Well As From Apple And Plum Kernels Were Employed As Catalysts In The Form Of Defatted Meal. A Number Of Factors Influencing The Hydrocyanation Process Have Been Studied And The Conditions Optimised Using Statistical Methods. (R)-Pantolactone With 74% Yield And 30% Ee Has Been Synthesised.
DOI:10.1021/op050186S

专利信息

专利号:WO-2023078722-A1
优先权日:2021-11-02
标题 :Synthesis of pantothenic acid butyrate
发明人：BONRATH WERNER; EGGERTSWYLER CHRISTOPHE; PACE FRANCESCO
权利人:DSM IP ASSETS BV
摘要:The present invention relates to new specific butyrate compounds to a new and improved synthesis of specific butyrates as well their use. Butyrate compounds are very useful compounds, either as such or as intermediates in organic synthesis.

专利号:WO-2019228873-A1
优先权日:2018-05-31
标 题:Synthesis of a racemic mixture of pantolactone
发明人：BONRATH WERNER; BOURGEOIS FREDERIC; MEDLOCK JONATHAN; SPARR CHRISTOF
权利人:DSM IP ASSETS BV
摘要:The invention relates to an improved synthesis of a racemic mixture of pantolactone (I).

专利号:WO-2019228874-A1
优先权日:2018-05-31
标 题 :Stereoselective synthesis of enantiomerically-enriched pantolactone
发明人：BONRATH WERNER; BOURGEOIS FREDERIC; MEDLOCK JONATHAN; SPARR CHRISTOF
权利人:DSM IP ASSETS BV
摘要:The present invention relates stereoselective synthesis of enantiomerically enriched pantolactone.

专利号:US-4879389-A
优先权日:1986-06-25
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO
权利人:ACHIWA KAZUO
摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:EP-3819295-A1
优先权日:2019-11-07
标 题 :Stereoselective synthesis of enantiomerically-enriched pantolactone
发明人：BONRATH WERNER; BOURGEOIS FREDERIC; MEDLOCK JONATHAN ALAN; SPARR CHRISTOF
权利人:DSM IP ASSETS BV
摘要:The present invention relates stereoselective synthesis of enantiomerically enriched pantolactone of formula (I) or (I').

专利号:US-4985567-A
优先权日:1988-03-07
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO; TAKEDA HIDEO
权利人:KAZUO ACHIWA; FUJI YAKUHIN KOGYO KK
摘要:New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R 1 is hydrogen or --COA 1 , --COOA 2 , --CONHA 3 , --SO 2 A 4 or --PO(A 5 ) 2 , A 1 , A 2 , A 3 , A 4 and A 5 each represents independently alkyl or aryl, R 2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R 3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R 2 and R 3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.