CAS: 503-01-5; N,6-Dimethylhept-5-En-2-Amine

上下游产品

CAS号110-93-0 甲基庚烯酮 | CAS号74-89-5 氨基甲烷 | CAS号593-51-1 一甲胺盐酸盐 | CAS号50-00-0 甲醛 | CAS号22462-79-9 6-methylhept-5-... | CAS号63958-97-4 2-methyl-6-(met...

📜6-甲基-5-庚烯-2-酮,盐酸甲胺置于sodium Cyanoborohydride,Potassium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应 0.17H,以52%的收率获得产物异美汀
参考文献:通过超分子组装催化的 Aza-Prins 环化中的缩窄结合实现新的反应模式
标题:通过超分子组装催化的 Aza-Prins 环化中的缩窄结合实现新的反应模式
摘要:超分子组装 1 催化双分子 Aza-Prins 环化,其特征是意想不到的跨环 1,5-氢化物转移.这种反应途径由 1 的超分子腔内的收缩结合促进,在没有 1 的情况下在动力学上是不利的,正如在本体溶液中观测到的正交反应性所证明的那样.通过动力学分析和同位素标记研究进行的机理研究表明,转化的限速步骤是瞬态亚胺离子的封装,并支持拟议的 1,5-氢化物转移机制.这是在催化金属配体超分子酶模拟物中观测到的这种产品选择性极端差异的罕见例子.
DOI:10.1021/jacs.5B01261

专利信息

专利号:US-8604004-B2
优先权日:2007-10-04
标 题 :Moenomycin analogs, methods of synthesis, and uses thereof
发明人：KAHNE DANIEL; KAHNE SUZANNE WALKER; ADACHI MASAATSU; DOUD EMMA; FUSE SHINICHIRO; LIN XIAONAN; ZHANG YI; TSUKAMOTO HIROKAZU; OSTASH BOHDAN
权利人:KAHNE DANIEL; KAHNE SUZANNE WALKER; ADACHI MASAATSU; DOUD EMMA; FUSE SHINICHIRO; LIN XIAONAN; ZHANG YI; TSUKAMOTO HIROKAZU; OSTASH BOHDAN; HARVARD COLLEGE
摘要:The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.

专利号:US-6787668-B2
优先权日:2000-04-13
标 题 :2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
发明人：PITZELE BARNETT S; SIKORSKI JAMES A; WEBBER RONALD KEITH
权利人:PHARMACIA CORP
摘要:The present invention is directed to a compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:R1 is selected from the group consisting of H and methyl; andR2 is selected from the group consisting of H and methyl.The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.

专利号:RU-2399413-C2
优先权日:2008-09-02
标 题 :Catalyst for synthesis of 1-(dimethylamino)-3-alkyl-2-propines

专利号:RU-2440341-C2
优先权日:2009-12-07
标 题 :Method for combined synthesis of 4-alkylquinoline and (2,3-dialkyl-4-quinolinyl)-n, n-dimethylmethane amine

专利号:JP-2002522555-A
优先权日:1998-08-14
标题 :Chemical synthesis of exochelin

专利号:US-9403755-B2
优先权日:2013-01-18
标 题:Isometheptene isomer
发明人：LEDERMAN SETH; DAUGHERTY BRUCE; GERSHELL LELAND J; RIDEOUT DARRYL; KAWASAKI ANDREW
权利人:TONIX PHARMACEUTICALS INC; TONIX PHARMA HOLDINGS LTD (BERMUDA)
摘要:The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), n nor a hydrochloride, or a pharmaceutically acceptable addition salt thereof. In particular, the disclosure relates to the synthesis, purification and characterization of an Isometheptene isomer mucate crystal 2, wherein the Isometheptene isomer 2 is stereochemically characterized as (R)-enantiomer, respectively. The Isometheptene (R)-enantiomer activity indicates a selective centrally acting selective ligand for Imidazoline subtype 1 (I1) receptor sites; and more specifically, the disclosure provides an antihypertensive composition for treatment of migraine and other neurovascular or neurogenic pain from abdominal distress. (R)-Isometheptene enantiomer or isomer 2 may be an anti-hypertensive agent with lower side effects than the racemate form. Therefore (R)-Isometheptene is believed to be effective against episodic tension-type headaches (ETTH). The (R)-Isometheptene enantiomer or isomer 2 is believed to effectively lower blood pressure, used alone or together with other headache ameliorating drugs. Methods of synthesis and treatment are described. Regarding (R)-Isometheptene crystals data of X-ray crystallography are presented.