CAS: 4470-83-1; 2,8-Dichloroquinoline

相似化合物

611-33-6 1810-72-6 613-77-4

上下游产品

8-chloroquinoline-N-oxide 8-chloroquinoline 2-chloroaniline hydr°Chloride 2,8-dichloroquinoline-3-carbaldehyde 2-{4-[(8-chloroquinolin-2-yl)amino]phenoxy}ethan-1-ol N-[1-adamantyl(phenyl)methyl]-8-chloroquinolin-2-amine 8-chloroquinoline

8-氯喹啉-N-氧化物置于三氯氧磷体系中,化学反应 3.0H,以52%的收率获得产物2,8-二氯喹啉
参考文献:的合成ñ-Chloroquinolines和ñ-Ethynylquinolines(ñ均聚物和heterocoupling反应:= 2,4,8)
标题:的合成ñ-Chloroquinolines和ñ-Ethynylquinolines(ñ均聚物和heterocoupling反应:= 2,4,8)
摘要:所述ñ-(乙炔基)喹啉得到令人满意的通过将适当之间heterocoupling反应制备ñ-Chloroquinoline和2-甲基-3-丁炔-2-醇,通过钯催化,随后用氢氧化钠粉末在甲苯中的催化剂量.在氯化亚铜的催化下,通过氧化二聚作用将n-(乙炔基)喹啉转化为相应的共轭1,4-双[N '-((quinolyl)] Buta-1,3-Diynes.此外,Heterocoupling之间ñ '-Haloquinoline和ñ '-(乙炔基)喹啉(ñ由钯催化的',2'或3')分别得到2',2'-双(喹啉)或1,2-二(3'-喹啉基)乙炔.与零价镍配合物相同的偶联反应中,使1,2,4-和1,3,5-三(的混合物ñ '喹啉基)苯.
DOI:10.1016/j.Tet.2005.07.043

专利信息

专利号:US-12084422-B2
优先权日:2018-07-09
标 题 :Phenyl-n-quinoline derivatives for treating a RNA virus infection
发明人：SCHERRER DIDIER; TAZI JAMAL; MAHUTEAU-BETZER FLORENCE; NAJMAN ROMAIN; SANTO JULIEN; APOLIT CÉCILE
权利人:ABIVAX; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER; INST CURIE
摘要:A compound of formula (I) or any of its pharmaceutically acceptable salt for use in the treatment and/or prevention of a RNA virus infection, and a RNA virus infection from group IV or V of the Baltimore classificationwherein R3 represents a chlorine atom or a hydrogen atom, R represents a (C1-C4)alkyl group, a (C3-C6)cycloalkyl group, a halogen atom, a (C1-C5)alkoxy group, a —SO2—NRaRb group, a —SO3H group, a —OH group, a —O—SO2—ORc group or a —O—P(â•?O)—(ORc)(ORd) group, R1 represents (i) a CF3 group, (ii) a (C1-C10)alkyl group, (iii) a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group or (iv) a phenyl group or a naphthyl group, and R2 represents a hydrogen atom, a (C1-C10)alkyl group, a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group and further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.