CAS: 4077-76-3; Dimethyl 1H-Pyrazole-3,5-Dicarboxylate

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Dimethyl 4,5-Dihydro-1H-Pyrazole-3,5-Dicarboxylate置于氯体系中,化学反应生成 吡唑-3,5-二羧酸二甲酯
参考文献:über Pyrazol-Karbonsäure-Amide
标题:über Pyrazol-Karbonsäure-Amide
摘要:
DOI:10.1002/ardp.19432810403

专利信息

专利号:US-8952042-B2
优先权日:2009-08-19
标 题 :FXR (NR1H4) binding and activity modulating compounds
发明人：KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF
权利人:KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF; PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds of formula (1): n nwhere R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

专利号:CN-109627235-A
优先权日:2018-11-26
标 题 :A kind of high-energy insensitive energetic compound and its synthesis method