专利号:US-7799524-B2 优先权日:2002-10-03 标 题:Substrates for O6-alkylguanina-DNA alkyltransferase 发明人:KINDERMANN MAIK; JOHNSSON KAI; BIERI CHRISTOPH 权利人:ECOLE POLYTECHNIQUE FERDEALE D 摘要:The invention relates to compounds of formula 1 n nwherein R 1 -R 2 is a guanine derivative; X is oxygen or sulfur; R 3 is a heteroaromatic, unsaturated heterocyclyl or an alkynyl group with the double or triple bond connected to CH 2 ; R 4 is a linker; and L is a label, a plurality of same or different labels, a bond connecting R 4 to R 1 forming a cyclic substrate, or a further group —R 3 —CH 2 —X—R 1 -R 2 . The invention relates also to methods of manufacture of such novel AGT substrates, to intermediates useful in the synthesis of such AGT substrates, and to a method of transferring a label from such AGT substrates to O 6 -alkylguanine-DNA alkyltransferase (AGT) fusion proteins comprising proteins of interest.
专利号:US-6762281-B2 优先权日:2000-09-08 标题:Process for preparing peptide derivatized oligomeric compounds 发明人:MANOHARAN MUTHIAH; GUZAEV ANDREI P 权利人:ISIS PHARMACEUTICALS INC 摘要:Methods of preparing peptide linked oligomeric compounds are provided. The method is useful for preparing larger scale amounts of peptide linked oligomeric compounds. More particularly, the synthesis of peptide linked oligomeric compounds is performed without the problems of aggregation associated with electrostatic interactions. The present method describes using equimolar amounts of oligomeric compounds and peptide reagents providing for an increase in overall efficiency.
专利号:US-11511238-B1 优先权日:2021-07-20 标 题 :Composite covalent organic framework membranes 发明人:BIKSON BENJAMIN 权利人:Avanpore LLC 摘要:Disclosed is the preparation of composite fluid separation membranes based on poly (aryl ether ketone) (PAEK) polymers with the separation layer formed by a layer-by-layer reticular synthesis. The porous PAEK substrate is semicrystalline, exhibits a mesoporous surface structure, and is surface functionalized. The separation layer formed by the hierarchical layer-by-layer process is in the form of a covalent organic network integrally linked via covalent bonds to the functional groups of the substrate. The composite separation layer may be synthesized in situ in a preformed separation device on the surface of the PAEK substrate. Device configurations include flat sheet, spiral wound, monolith, and hollow fiber configurations with the hollow fiber configuration being preferred. Hollow fibers are formed from PAEK polymers with poly (ether ether ketone) and poly (ether ketone) particularly preferred. Composite PAEK membranes of the present invention are useful for a broad range of fluid separation applications.
专利号:US-9670305-B2 优先权日:2012-04-16 标 题 :Polyurethane dispersant and the method for its preparation 发明人:WANG ZHIJUN 权利人:WANG ZHIJUN; AFCONA CHEMICALS (HAIMEN) CO LTD 摘要:The present invention is related to a polyurethane dispersant and a preparation method thereof. The polyurethane dispersant is terminated by a nitrogen-containing heterocyclic compound during synthesis. The nitrogen-containing heterocyclic compound is prepared by subjecting anhydride and a compound containing a primary amine and a secondary amine or a hydroxyl or mercapto group to dehydration condensation. The condensed product is the nitrogen-containing heterocyclic compound, containing a reactive hydrogen. The structural formula of the compound containing the primary amine and the secondary amine or hydroxyl or mercapto group is shown as follows: n nwherein n=1 to 5, and preferably 2 to 4, R 1 and R 2 are respectively alkyls containing 1 to 8 carbons, R 1 and R 2 are independent of each other or connected by a chemical bond to form one or more saturated or unsaturated 4-member to 8-member rings, and X represents N, O, or S.
专利号:US-2021093737-A1 优先权日:2013-03-15 标题 :Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
专利号:CN-104031048-B 优先权日:2014-05-28 标题 :A kind of β-chloroethylnitrosourea compound and its synthesis method and application