CAS: 38430-55-6; Ethyl 4-Acetylbenzoate

上下游产品

CAS号64-17-5 乙醇 | CAS号13329-40-3 4'-碘代苯乙酮 | CAS号201230-82-2 carbon monoxide | CAS号64101-67-3 4-acetylphenyl ... | CAS号123412-35-1 (4-acetylphenyl... | CAS号1906-57-6 乙基草酸钾 | CAS号99-90-1 4-溴苯乙酮 | CAS号5798-75-4 4-溴苯甲酸乙酯 | CAS号75-36-5 乙酰氯 | CAS号99-91-2 对氯苯乙酮 | CAS号179055-27-7 4-(1-甲基-1H-吡唑-3... | CAS号179055-28-8 4-(1-甲基-1H-吡唑-5... | CAS号179055-20-0 (4-(1-甲基-1H-吡唑-... | CAS号28357-95-1 4-(1-氨基乙基)苯甲酸 | CAS号870822-88-1 2-(1-(4-(乙氧基羰基)... | CAS号7398-52-9 2-(4-乙酰基苯基)乙酸 | CAS号75633-63-5 1-(4-(羟甲基)苯基)乙酮 | CAS号128310-70-3 (R)-4-(1-羟基乙基) 苯甲酸甲酯 | CAS号10266-42-9 4-acetylphenyla... | CAS号179057-10-4 (4-甲酸甲酯苯基)-3-吡唑

4-乙酰基苯甲酸置于硫酸体系中,用 乙醇 作为反应溶剂,化学反应 18.0H,以69%的收率获得产物4-乙酰基苯甲酸乙酯
参考文献:鉴定具有2-氨基噻唑部分的吡酸衍生物结合了双重pparα/γ激活和双重5-Lo / Mpges-1抑制
标题:鉴定具有2-氨基噻唑部分的吡酸衍生物结合了双重pparα/γ激活和双重5-Lo / Mpges-1抑制
摘要:最初提出双重pparα/γ激活的概念作为治疗代谢综合征的新方法.但是,最近的结果表明,Pparα以及pparγ活化也可能对炎症性疾病和癌症的治疗有益.我们最近已确定氨基噻唑为特征的吡rin酸为双5-脂氧合酶(5-Lo)和微粒体前列腺素e 2合酶1(mpges-1)抑制剂.在这里,我们介绍了这些氨基噻唑特征的吡rin酸作为双重pparα/γ激动剂的结构与活性之间的关系,并讨论了它们作为双重5-Lo / Mpges-1抑制剂在炎性和癌症疾病中的潜力的优势.多种吡喃酸衍生物已被确定为双重pparα/γ激动剂.然而,在这一系列氨基噻唑特色的吡rin酸中,我们能够鉴定出最有效的选择性pparγ激动性吡rin酸衍生物(化合物13,(2-[(4-氯-6-{[4-(萘-2-基)-1,3-噻唑-2-基]氨基}嘧啶-2-基)硫烷基]辛酸)).因此,进行13在pparγ上的对接以确定潜在的结合模式.
DOI:10.1016/j.Bmcl.2014.06.077

专利信息

专利号:US-6720439-B1
优先权日:2001-09-28
标题:Synthesis of ruthenium-hydride complexes and preparation procedures of chiral alcohols and ketones
发明人：OHKUMA TAKESHI; KOIZUMI MASATOSHI; MUNIZ KILIAN; NOYORI RYOJI
权利人:INST NAGOYA IND SCIENCE RES
摘要:trans-RuH(eta<1>-BH4)[(S)-xylbinap][(S,S)-dpen] (0.00125 mmol), acetophenone (5.0 mmol), and 2-propanol (2.5 mL) were placed in an autoclave, and the resulting solution was repeatedly subject 5 times to a procedure of performing pressure reduction and argon introduction while stirring the solution for deaeration. A hydrogen tank was then connected to the autoclave, and after replacing the air inside an introduction tube with hydrogen, the pressure inside the autoclave was adjusted to 5 atmospheres and then hydrogen was released until the pressure dropped to 1 atmosphere. After repeating this procedure 10 times, the hydrogen pressure was adjusted to 8 atmospheres and stirring at 25° C. was performed for 12 hours. By concentrating the solution obtained by depressurization and subjecting the crude product to simple distillation, (R)-1-phenylethanol (yield: 95%) in the form of a colorless oily substance was obtained at an ee of 99%.

专利号:US-6005103-A
优先权日:1993-11-19
标题 :Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

专利号:EP-0729465-B1
优先权日:1993-11-19
标 题:Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:PARKE DAVIS & CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.