CAS: 35144-22-0; 4,6-Dimethyl-2-Methylsulfonylpyrimidine

上下游产品

4,6-dimethyl-2-methylsulfanyl-pyrimidine 4,6-dimethyl-2-meraptopyrimidine 4,6-dimethyl-2-(piperazin-1-yl)pyrimidine (S)-methyl-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate Lu 224332 Feloprentan

4,6-二甲基-2-巯基嘧啶置于sodium Hydroxide,甲酸,双氧水体系中,化学反应 10.0H,反应生成 4,6-二甲基-2-甲磺酰基嘧啶
参考文献:N-取代的环状酰亚胺(1R *,2S *,3R *,4S *)-N-[4-[4-(2-嘧啶基)-1-哌嗪基]丁基]-2,3-双环的合成及抗焦虑活性[2.2.1]庚烷二甲酰亚胺(tandospirone)和相关化合物.
标题:N-取代的环状酰亚胺(1R *,2S *,3R *,4S *)-N-[4-[4-(2-嘧啶基)-1-哌嗪基]丁基]-2,3-双环的合成及抗焦虑活性[2.2.1]庚烷二甲酰亚胺(tandospirone)和相关化合物.
摘要:合成了一系列带有ω-(4-芳基和4-杂芳基-1-哌嗪基)烷基的环状酰亚胺,并在体内测试其抗焦虑活性.还检查了这些化合物的体外结合亲和力的5-Ht1A受体位点.讨论了这些系列中的构效关系.这些化合物之一,(1R *,2S *,-3R *,4S *)-N-[4-[4-(4-嘧啶基)-1-哌嗪基]丁基]-2,3-双环[2.2.1已发现]庚烷二甲酰亚胺(1:Tandospirone)与丁螺环酮具有相同的抗焦虑活性,并且比丁螺环酮和地西epa具有更高的选择性.tandospirone(1)目前正在作为一种选择性抗焦虑药进行临床评估.
DOI:10.1248/cpb.39.2288

专利信息

专利号:EP-0623613-A1
优先权日:1993-05-03
标题 :Fungicidal spiroheterocyclic compounds
发明人：PFRENGLE WALDEMAR FRANZ AUGUST
权利人:SHELL INT RESEARCH
摘要:New fungicidal spiroheterocyclic compounds are described, having the general formula I,n n in whichn X represents O or CHâ‚‚, R¹ represents a hydrogen atom or an optionally substituted alkyl, cycloalkyl, haloalkyl, alkenyl, alkynyl, aryl or aralkyl group, R² or each R² independently represents an optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkoxyalkyl, aryl or aryloxy group, or R² or each R², together with the ring to which they are attached, represents a polycyclic hydrocarbyl group, A and B both represent a nitrogen atom, or A represents a group CRâ?µ and B represents a nitrogen atom or a group CRâ?¶, R³, Râ?´, Râ?µ and Râ?¶ each independently represent a hydrogen or halogen atom, a hydroxy or cyano group or an optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, aralkyl, aryl, alkylamino, alkylthio or alkoxy or group, l represents an integer from 1 to 3, m represents zero or an integer from 1 to 6, and n represents zero or an integer from 1 to 3. n The invention further relates to the preparation of the above spiroheterocyclic compounds, intermediates prepared during the synthesis of these compounds, compositions containing the compounds and their use as fungicides in the controlof undesired plant growth.