专利号:US-4788354-A 优先权日:1984-10-16 标 题 :Method for the synthesis of iodobenzene 发明人:PAPARATTO GIUSEPPE; SAETTI MARCO 权利人:MONTEDIPE SPA 摘要:A method for the synthesis of iodobenzene by iodination, in the gaseous phase, of benzene with iodine, in the presence of a zeolitic catalyst, selected from the group comprising the zeolites of X type or of Y type, characterized in that said iodination is an oxidative one and that said zeolites are in a form different from the acid (H) form.
专利号:US-2008287407-A1 优先权日:2003-12-10 标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use 发明人:GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI 权利人:NITROMED INC 摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.
专利号:US-4048220-A 优先权日:1975-05-30 标题:Process for preparation of 1,4-haloallylic esters from dienes 发明人:CARDENAS CARLOS G 权利人:SCM CORP 摘要:A process for the synthesis of 1,4-haloallylic esters from conjugated dienes which comprises preparing a reaction mixture of the conjugated diene, a halogenating agent, and a carboxylic acid and then adding to said reaction mixture a catalytic amount of a strong acid having a high dissociation constant. The invention is particularly described with reference to the synthesis of isoprene-1,4-chloroacetate(1-chloro-4-acetoxy-2-methyl-2-butene) from isoprene wherein a reaction mixture is prepared of isoprene with t-butyl hypochlorite in excess glacial acetic acid, to which is added H2SO4 followed by stirring at 50 DEG C.
专利号:US-9284266-B2 优先权日:2012-01-19 标题:Method for synthesizing ramalin and ramalin precursor by using glutamic acid derivative and hydroxy aniline or hydroxy aniline having protected hydroxy group 发明人:YIM JOUNG HAN; KIM IL CHAN; KIM DOCKYU; HAN SE JONG; LEE HYOUNG SEOK; BHATTARAI HARI DATTA; KIM TAI KYOUNG; KIM KEUN SIK 权利人:YIM JOUNG HAN; KIM IL CHAN; KIM DOCKYU; HAN SE JONG; LEE HYOUNG SEOK; BHATTARAI HARI DATTA; KIM TAI KYOUNG; KIM KEUN SIK; KOREA INST OF OCEAN SCIENCE AND TECHNOLOGY 摘要:Disclosed is a method of the synthesis of ramalin. It comprises reacting a glutamic acid derivative, which is prepared using alkylchloroformate, with a hydrazine salt compound, which is prepared from hydroxy aniline, whether protected or not. The synthesis method allows ramalin, excellent in antioxidant and anti-inflammatory activity, to be simply synthesized at stable yield even without use of a highly toxic solvent such as DMF. In addition, the method is cost competitive, and provides ramalin at high efficiency, thus enabling the mass production of ramalin.
专利号:US-10981796-B2 优先权日:2016-12-13 标 题:Process for the preparation of a titanium-containing zeolite 发明人:PARVULESCU ANDREI-NICOLAE; MUELLER ULRICH; VOGELSANG REGINA; BRUNS NICOLE SABINE; WEIDERT JAN-OLIVER 权利人:BASF SE 摘要:A process comprising hydrothermally synthesizing a titanium-containing zeolitic material having framework type MWW in the presence of an MWW template compound, obtaining a mother liquor comprising water, a first portion of the MWW template compound and a titanium-containing zeolitic material having framework type MWW comprising a second portion of the MWW template compound, separating the first portion of the MWW template compound from the mother liquor and recycling the first portion of the MWW template compound into a hydrothermal synthesis of a titanium-containing zeolitic material having framework type MWW.
专利号:US-11629150-B2 优先权日:2016-07-01 标题:Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines 发明人:SMITH ALEXANDER; WHITE HANNAH S; TAVARES FRANCIS XAVIER; KRASUTSKY SERGIY; CHEN JIAN-XIE; DORROW ROBERTA L; ZHONG HUA 权利人:G1 THERAPEUTICS INC 摘要:This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.