CAS: 243469-59-2; 2,5-Anhydro-1-Azido-1-Deoxy-D-Glucitol

该化合物是一种属于糖类的化学化合物,其特点是糖脊有附着的Azido组(N3),特别是D-glucitol的衍生物.该化合物一般是白色到白色以外的固体,在水和甲醇等极地溶剂中可溶解.Azido组具有独特的再活动性,使其在各种化学合成应用中有用,特别是在生物凝聚和点击化学领域.其结构具有水力结构,有助于其稳定性和再活性特征.该化合物具有药用化学和碳水化合物的兴趣,因为它在药物开发中具有潜在用途,并且是更为复杂的分子的建筑块块.在处理该化合物时,应当注意安全防范措施,因为化合物可能敏感和具有潜在危险性.

英文名称2,5-Anhydro-1-Azido-1-Deoxy-D-Glucitol
中文名称2,5-脱水-1-叠氮-1-脱氧-D-葡萄糖醇
其它别名2,5-Anhydro-1-azido-1-deoxy-D-Glucitol
CAS编号243469-59-2
MFCD编号:MFCD11113469
分子式:C6H11N3O4分子量:189.17
产品CID: 1190464
产品分类化学试剂 → 有机试剂 → 叠氮

相似结构搜索
InChIKey: SXQJFSPBUVMKMT-SLPGGIOYSA-N
1S/C6H11N3O4/c7-9-8-1-3-5(11)6(12)4(2-10)13-3/h3-6,10-12H,1-2H2/t3-,4+,5+,6+/m0/s1
计算化学: 氢键受体数6.0氢键供体数3.0可旋转键数3.0

MSDS等安全信息

上下游产品

2,5-anhydro-1-azido-4,5-di-O-benzoyl-1-deoxy-D-glucitol 2,5-anhydro-1,3-O-isopropylidene-D-glucitol 2,5-anhydro-4,5-di-O-benzoyl-D-glucitol 2,5-anhydro-4,5-di-O-benzoyl-1,3-O-isopropylidene-D-glucitol 1-(3,4,6-tri-O-acetyl-2,5-anhydro-1-deoxy-D-glucitolyl)-4-(4-N,N-dimethylaminophenyl)-[1,2,3]-triazole 1-(3,4,6-tri-O-acetyl-2,5-anhydro-1-deoxy-D-glucitolyl)-4-(4-methoxyphenyl)-[1,2,3]-triazole 1-(3,4,6-tri-O-acetyl-2,5-anhydro-1-deoxy-D-glucitolyl)-4-(1-hydroxy-1-phenylmethyl)-[1,2,3]-triazole 1-(3,4,6-tri-O-acetyl-2,5-anhydro-1-deoxy-D-glucitolyl)-4-(1-hydroxycyclohexyl)-[1,2,3]-triazole

合成工艺路线路线简述

📜2,5-Anhydro-1,3-O-Isopropylidene-D-Glucitol置于sodium Azide,Sodium,溶剂黄146体系中,用吡啶,甲醇,N,N-二甲基甲酰胺用作溶剂,化学反应 93.0H,反应生成2,5-脱水-1-叠氮-1-脱氧-D-葡萄糖醇
参考文献:Ethambutol-sugar Hybrids As Potential Inhibitors Of Mycobacterial Cell-Wall Biosynthesis
标题:Ethambutol-sugar Hybrids As Potential Inhibitors Of Mycobacterial Cell-Wall Biosynthesis
摘要:Ethambutol Is An Established Front-Line Agent For The Treatment Of Tuberculosis,And Is Also Active Against Mycobacterium Avium Infection. However,This Agent Exhibits Toxicity,And Is Considered To Have Low Potency. The Action Of Ethambutol On The Mycobacterial Cell Wall,Particularly The Arabinan,And Comparison Of The Structure Of Ethambutol With Several Of The Cell-Wall Saccharides,Suggested That Ethambutol-Saccharide Hybrids Might Lead To Agents With A More Selective Mechanism Of Action. To This End,Eight Ethambutol-Saccharide Hybrids Were Synthesized And Screened Against M. Tuberculosis And Several Clinical Isolates Of M. Avium. (C) 1999 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0008-6215(99)00069-5