CAS: 187671-16-5; Fmoc-Asp-Ofm

相似化合物

144120-53-6 204246-17-3 86060-83-5

上下游产品

9-Fluorenylmethanol Fm°C-(tBu)Asp-OH(3S,6S)-2,5-dioxopiperazine-3,6-diacetic acid

📜Fmoc-Asp(Otbu)-Ofm置于三氟乙酸体系中,用 水 用作溶剂,化学反应 3.0H,以42 G的收率获得n-芴甲氧羰基-L-天冬氨酸 1-芴甲基酯
参考文献:一类含天冬氨酸,谷氨酸的环二肽的合成方法
标题:一类含天冬氨酸,谷氨酸的环二肽的合成方法
摘要:本发明公开了一类含天冬氨酸,谷氨酸的环二肽的合成方法,该方法是以fmoc‑asp(Otbu)‑oh或fmoc‑glu(Otbu)‑oh为原料,与9‑芴甲醇反应得到全保护氨基酸的芴甲酯,然后脱除侧链叔丁氧基,得到保护氨基酸fmoc‑asp‑ofm或fmoc‑glu‑ofm;再以2‑ctc Resin树脂为载体与fmoc‑asp‑ofm或fmoc‑glu‑ofm侧链γ‑羧基键合,固相环化合成全保护环二肽,切割裂解得到碳端为天冬氨酸或谷氨酸的环二肽.该方法通过引入9‑芴甲醇保护羧基,在固相合成二肽的过程中可顺利除去,整个过程操作简单,固相环合效率高,纯度高,可适用于批量化合成碳端为天冬氨酸或谷氨酸的环二肽.

专利信息

专利号:US-2003004122-A1
优先权日:1997-11-05
标 题 :Nucleotide triphosphates and their incorporation into oligonucleotides
发明人：BEIGELMAN LEONID; BURGIN ALEX; BEAUDRY AMBER; KARPEISKY ALEXANDER; MATULIC-ADAMIC JASENKA; SWEEDLER DAVID; ZINNEN SHAWN
摘要:The present invention relates to novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes or DNAzymes). Also, provided are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.

专利号:US-6528640-B1
优先权日:1997-11-05
标题 :Synthetic ribonucleic acids with RNAse activity
发明人：BEIGELMAN LEONID; BURGIN ALEX; BEAUDRY AMBER; KARPEISKY ALEXANDER; MATULIC-ADAMIC JASENKA; SWEEDLER DAVID; ZINNEN SHAWN
权利人:RIBOZYME PHARM INC
摘要:Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.

专利号:US-6617438-B1
优先权日:1997-11-05
标 题 :Oligoribonucleotides with enzymatic activity
发明人：BEIGELMAN LEONID; BURGIN ALEX B; BEAUDRY AMBER; KARPEISKY ALEXANDER; MATULIC-ADAMIC JASENKA; SWEEDLER DAVID; ZINNEN SHAWN
权利人:SIRNA THERAPEUTICS INC
摘要:Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.