CAS: 1665-48-1; 5-((3,5-Dimethylphenoxy)Methyl)Oxazolidin-2-One

相似化合物

86181-90-0 5057-74-9 312598-51-9

上下游产品

CAS号105-67-9 2,4-二甲基苯酚 | CAS号2451-62-9 异氰尿酸三缩水甘油酯 | CAS号108-68-9 3,5-二甲基苯酚 | CAS号66766-07-2 1-Amino-3-(3,5-... | CAS号598-55-0 氨基甲酸甲酯 | CAS号59365-66-1 3-(3,5-二甲基苯氧基)-... | CAS号57-13-6 尿素 | CAS号153756-95-7 4-acetamidophen...

📜3,5-二甲基苯酚置于halohydrin Dehalogenase S195T/v92W/f240S Mutant From Acidimicrobiia Bacterium,Potassium Hydroxide体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 24.0H,反应生成美他沙酮
参考文献:美他沙酮及其类似物的生物催化合成
标题:美他沙酮及其类似物的生物催化合成
摘要:基于卤代醇脱卤酶催化环氧化物和氰酸酯的反应,开发了一种合成美他沙酮及其类似物的生物催化方法.通过对来自acidimicrobiia 细菌的卤代醇脱卤酶 Hhdhamb 进行蛋白质工程改造,实现了手性和外消旋美他沙酮的克级合成,产率分别为 44% (98% Ee ) 和 81%.此外,合成了各种美他沙酮类似物,手性形式的收率为 28-40% (90-99% Ee ),外消旋形式的收率为 77-92%.
Doi:10.1021/acs.Orglett.3C01752

专利信息

专利号:US-8877930-B2
优先权日:2009-11-04
标 题 :Continuous flow synthesis of amino alcohols using microreactors
发明人：BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F
权利人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F; MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.

专利号:US-7309799-B2
优先权日:2004-06-01
标 题:Methods for the synthesis of milnacipran and congeners thereof
发明人：BUCHWALD STEPHEN L; SWAGER TIMOTHY M; RARIY ROMAN V
权利人:COLLEGIUM PHARMACEUTICAL INC
摘要:One aspect of the present invention relates to methods for synthesizing milnacipran or congeners thereof. Another aspect of the present invention relates to asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof. The present invention also relates to methods for synthesizing intermediates useful in the non-asymmetric or asymmetric methods for synthesizing enantiomerically enriched milnacipran or congeners thereof.

专利号:WO-2023061999-A1
优先权日:2021-10-12
标 题 :Process for preparing a phenolic hydrocarbon
发明人：CORNELLA JOSEP; LE VAILLANT FRANCK
权利人:STUDIENGESELLSCHAFT KOHLE GGMBH
摘要:The present invention discloses a distinct mode of action of a nickel catalyst to forge C-0 bonds to unlock the mild utilization of N2O as O-atom transfer reagent in the synthesis of complex phenols from the corresponding aryl halides.

专利号:US-2005282898-A1
优先权日:2004-06-01
标 题 :Methods for the synthesis of milnacipran and congeners thereof

专利号:US-2011118469-A1
优先权日:2009-11-04
标题 :Continuous flow synthesis of amino alcohols using microreactors

专利号:US-9265748-B2
优先权日:2011-08-11
标题 :Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use
发明人：RAILLARD STEPHEN P; MANTHATI SURESH K; JOSHI SUDHIR
权利人:XENOPORT INC
摘要:Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.