CAS: 156973-09-0; 5-(Aminomethyl)Pyridin-2-Amine

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CAS号4214-73-7 2-氨基-5-氰基吡啶 | CAS号329-89-5 6-氨基烟酰胺

📜6-氨基烟酰胺置于盐酸,硼烷体系中,化学反应生成6-氨基-(9Ci)-3-吡啶甲胺
参考文献:Discovery Of A Novel,Selective,And Orally Bioavailable Class Of Thrombin Inhibitors Incorporating Aminopyridyl Moieties At The P1 Position
标题:Discovery Of A Novel,Selective,And Orally Bioavailable Class Of Thrombin Inhibitors Incorporating Aminopyridyl Moieties At The P1 Position
摘要:A Novel Class Of Thrombin Inhibitors Incorporating Aminopyridyl Moieties At The P1 Position Has Been Discovered. Four Of These Thrombin Inhibitors (13B,C,E And 14D) Showed Nanomolar Potency (K-I 0.8-12 Nm),300-1500-Fold Selectivity For Thrombin Compared With Trypsin,And Good Oral Bioavailability (F = 40-76%) In Rats Or Dogs. The Neutral Fl Was Expected To Increase Metabolic Stability And Oral Absorption. Identification Of This Novel Aminopyridyl Group At Fl Was A Key Step In Our Search For A Clinical Candidate.
Doi:10.1021/jm970493R

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-117510471-A
优先权日:2022-07-29
标题 :A kind of synthesis method of abeciclib