CAS: 156-56-9; (S)-2-Amino-3-((R)-2-Methylenecyclopropyl)Propanoic Acid

上下游产品

(2S,4R) α-<(Methylenecyclopropyl)Methyl>Glycine Methyl Ester 144604-83-1

📜(2S,4Rs)-2-Hydroxy-4-Phenylsulfonyl-5-Trimethylsilyl-1-Pentyl P-Toluenesulfonate置于吡啶,盐酸,Lithium Hydroxide,正丁基锂,四丁基氟化铵,Potassium Carbonate,对甲苯磺酰氯,Lithium Diisopropyl Amide体系中,用 四氢呋喃,甲醇,四氯化碳,乙醚,正己烷,水 用作溶剂,化学反应 121.92H,反应生成(2S)-2-氨基-3-[(1S)-2-亚甲基环丙基]丙酸
参考文献:低血糖素a的各个非对映异构体的不对称全合成.
标题:低血糖素a的各个非对映异构体的不对称全合成.
摘要:利用sharpless环氧化法合成了构成非寻常的含有α-氨基酸次糖苷a的不寻常的亚甲基环丙烷的各个非对映异构体,以允许不对称的亚甲基环丙烷的合成.
Doi:10.1016/s0040-4020(01)89313-3

专利信息

专利号:US-7452701-B2
优先权日:1998-11-24
标 题:Methods for the preparation of β-amino acids
发明人：FREY PERRY A; RUZICKA FRANK J
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare β-amino acids by methods that avoid the pitfalls of chemical synthesis. The present invention provides a method of producing enantiomerically pure β-amino acids from α-amino acids comprising catalyzing the conversion of an α-amino acid to a corresponding β-amino acid by utilizing a lysine 2,3-aminomutase as the catalyst.

专利号:US-2020330400-A1
优先权日:2016-03-16
标 题:Methods for the treatment of cancer using coenzyme q10 and fatty acid metabolism inhibitors
发明人：GESTA STEPHANE; DIERS ANNE R; DADALI-ABEL TULIN
权利人:BERG LLC
摘要:Presented herein are methods for the treatment of oncological disorders by the co-administration of CoQ10 compositions and at least one fatty acid metabolism inhibitor. In one embodiment, the CoQ10 compositions are lipid-containing compositions. The fatty acid metabolism inhibitor may be an inhibitor of fatty acid synthesis, storage, transport or degradation. The fatty acid metabolism inhibitor may also be a modulator of fatty acid structure, for example a fatty acid desaturase or elongase. The fatty acid inhibitor may inhibit any molecule involved in fatty acid metabolism, such as fatty acid synthase (FASN), carnitine palmitoyltransferase 1 (CPT-1), long-chain 3-ketoacyl-CoA thiolase, or stearoyl-CoA desaturase-1 (SCD-1). In embodiments, the fatty acid metabolism inhibitor may be C75, Etomoxir, trimetazidine or A939572.

专利号:US-3880838-A
优先权日:1970-12-16
标 题 :Amino acid derivatives
发明人：BODANSZKY MIKLOS
权利人:SQUIBB & SONS INC
摘要:New lactone intermediates useful in the synthesis of peptides are prepared by reacting an Alpha -amino acid with an active carbonyl compound which forms a Schiff''s base. The latter is treated with a condensing agent so that cyclization occurs and a lactone is formed from which a peptide may be produced by reaction with an amino acid ester and removal of the protecting groups.

专利号:US-3957760-A
优先权日:1970-12-16
标 题:Amino acid derivatives
发明人：BODANSZKY MIKLOS
权利人:SQUIBB & SONS INC
摘要:New lactone intermediates useful in the synthesis of peptides are prepared by reacting an α-amino acid with an active carbonyl compound which forms a Schiff's base. The latter is treated with a condensing agent so that cyclization occurs and a lactone is formed from which a peptide may be produced by reaction with an amino acid ester and removal of the protecting groups.

专利号:US-3704246-A
优先权日:1970-12-16
标 题 :Amino acid derivatives
发明人：BODANSZKY MIKLOS
权利人:SQUIBB & SONS INC
摘要:NEW LACTONE INTERMEDIATES USEFUL IN THE SYNTHESIS OF PEPTIDES ARE PREPARED BY REACTING AN A-AMINO ACID WITH AN ACTIVE CARBONYL COMPOUND WHICH FORMS A SCHIFF''S BASE. THE LATTER IS TREATED WITH A CONDENSING AGENT SO THAT CYCLIZATION OCCURS AND A LACTONE IS FORMED FROM WHICH A PEPTIDE MAY BE PRODUCED BY REACTION WITH AN AMINO ACID ESTER REMOVAL OF THE PROTECTING GROUPS.