CAS: 1414-45-5; Nisin

专利信息

专利号:US-11571456-B2
优先权日:2017-05-23
标题 :Process for the linear synthesis of gram-positive class II bacteriocins and compositions and uses thereof
发明人：BÉDARD FRANÇOIS; BIRON ÉRIC; HAMMAMI RIADH; FLISS ISMAIL
权利人:UNIV LAVAL
摘要:A process for the linear synthesis of a gram-positive class II bacteriocin or a variant thereof is disclosed herein. The process comprises the stepwise addition of selected amino acids to a solid support; pseudoproline positioning and reopening; and cleavage of the gram-positive class II bacteriocin or the variant thereof from the solid support to provide a linear gram-positive class II bacteriocin or variant thereof; and in situ disulfide bond formation. Various applications and uses of the synthetic bacteriocins are also disclosed. The synthetic process can also be used to synthesize variants of bacteriocins by the selective substitution of one or more amino acids and/or additions and/or deletions of selected amino acids.

专利号:US-2023337702-A1
优先权日:2017-05-23
标 题 :Process for the linear synthesis of gram-positive class ii bacteriocins and compositions and uses thereof
发明人：BÉDARD FRANÇOIS; BIRON ÉRIC; HAMMAMI RIADH; FLISS ISMAIL; RENAUD ARIANE; DALLAIRE LAURENT
权利人:UNIV LAVAL
摘要:A process for the linear synthesis of a gram-positive class II bacteriocin or a variant thereof is disclosed herein. The process comprises the stepwise addition of selected amino acids to a solid support; pseudoproline positioning and reopening; and cleavage of the gram-positive class II bacteriocin or the variant thereof from the solid support to provide a linear gram-positive class II bacteriocin or variant thereof; and in situ disulfide bond formation. Various applications and uses of the synthetic bacteriocins are also disclosed. The synthetic process can also be used to synthesize variants of bacteriocins by the selective substitution of one or more amino acids and/or additions and/or deletions of selected amino acids.

专利号:US-2021023168-A1
优先权日:2017-05-23
标 题:Process for the linear synthesis of gram-positive class ii bacteriocins and compositions and uses thereof

专利号:EP-3630797-A1
优先权日:2017-05-23
标 题 :Process for the linear synthesis of gram-positive class ii bacteriocins and compositions and uses thereof