CAS: 13781-67-4; 2-(Thiophen-3-yl)Ethanol

上下游产品

CAS号6964-21-2 噻吩-3-乙酸 | CAS号58414-52-1 噻吩-3-乙酸甲酯 | CAS号872-31-1 3-溴噻吩 | CAS号1072-53-3 1,3,2-二噁唑噻吩-2,2-二氧化物 | CAS号75-21-8 环氧乙烷 | CAS号1505-47-1 4-(噻吩-3-基)丁酸 | CAS号19995-15-4 diethyl 2-(2-th... | CAS号19995-16-5 2-(2-thiophen-3... | CAS号616-44-4 3-甲基噻吩 | CAS号1283095-50-0 2-fluorospiro[4... | CAS号1283095-47-5 4,5-二氢螺[哌啶-4,7-... | CAS号1468-84-4 5,6-二氢苯并[B]噻吩-7... | CAS号13679-64-6 3-乙烯基噻吩 | CAS号13781-68-5 2-thiophen-3-yl... | CAS号16378-06-6 3-噻吩丙酸

3-噻吩乙酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应 3.0H,以98%的收率获得噻吩-3-乙醇
参考文献:新型spirobi [thieno [2,3-C] Pyran]的制备及其选择性单金属和双金属化:在可溶性共轭寡聚噻吩和p衍生物制备中的应用
标题:新型spirobi [thieno [2,3-C] Pyran]的制备及其选择性单金属和双金属化:在可溶性共轭寡聚噻吩和p衍生物制备中的应用
摘要:摘要 3-噻吩乙酸经六个步骤转化为新的螺双[thieno [2,3-C ] Pyran ](总收率:52%).将螺双[thieno [2,3-C ] Pyran]用丁基锂选择性地单金属化或双金属化,然后用氯化锌金属化;与各种芳基或杂芳基溴化物(包括溴-低聚噻吩,酰氯和1-溴py)的交叉偶联反应可高产率产生相应的螺衍生物. 3-噻吩乙酸经六个步骤转化为新的螺双[thieno [2,3-C ] Pyran ](总收率:52%).将螺双[thieno [2,3-C ] Pyran]用丁基锂选择性地单金属化或双金属化,然后用氯化锌金属化;与各种芳基或杂芳基溴化物(包括溴-低聚噻吩,酰氯和1-溴py)的交叉偶联反应可高产率产生相应的螺衍生物.
Doi:10.1055/s-0035-1560187

专利信息

专利号:US-6765117-B2
优先权日:1997-10-24
标题:Process for stereoselective synthesis of prostacyclin derivatives
发明人：MORIARTY ROBERT M; PENMASTA RAJU; GUO LIANG; RAO MUNAGALA S; STASZEWSKI JAMES P
权利人:UNITED THERAPEUTIC CORP
摘要:An improved method is described for making 9-deoxy-PGF 1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF 1 -type compounds.

专利号:US-5637757-A
优先权日:1995-04-11
标 题 :One-pot synthesis of ring-brominated benzoate compounds
发明人：HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
权利人:GREAT LAKES CHEMICAL CORP
摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-2002173672-A1
优先权日:1997-10-24
标 题:Process for stereoselective synthesis of prostacyclin derivatives

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-4305891-A
优先权日:1979-04-20
标题:Method for preparing O-4-(hydroxyalkyl)-thiophenyl phosphates
发明人：JONES FRANCIS W
权利人:COMMW SCIENT IND RES ORG
摘要:Organophosphorus esters, useful as intermediates in the synthesis of fibre-reactive insect proofing agents for keratinous materials, are prepared as follows: ##STR1## wherein: R 1 is an alkyl, alkoxy, alkylamino or alkylmercapto radical with 1-6 carbon atoms a dialkylamino radical of 2 to 6 carbon atoms or a phenyl or amino radical; n R 2 is an alkyl radical of 1-6 carbon atoms; n R 3 is a divalent alkylene radical of 1-12 carbon atoms; n X is either a sulphur or oxygen atom; and n hal is either a chlorine or bromine atom.