CAS: 116632-23-6; 3-Bromo-5-Nitrophenol

相似化合物

100367-38-2 16618-67-0 52427-05-1

上下游产品

3-Amino-5-nitro-phenol 3-bromo-5-nitroanisole hydrogen bromide 3,5-dibromonitrobenzene2-{2-[2-(3-bromo-5-nitro-phenoxy)-ethoxy]-ethoxy}-ethanol 1-(benzyloxy)-3-bromo-5-nitrobenzene 2-{2-[2-(3-amino-5-bromo-phenoxy)-ethoxy]-ethoxy}-ethanol acetic acid 2-{2-[2-(3-iodo-5-trimethylsilanylethynyl-phenoxy)-ethoxy]-ethoxy}-ethyl ester

📜2-氨基-5-硝基苯酚置于硫酸,溴体系中,用 乙醇,乙腈 用作溶剂,化学反应 4.0H,反应生成3-溴-5-硝基苯酚
参考文献:设计,合成和生物学评估作为有效的细菌ii型拓扑异构酶抑制剂的α-取代的异二十二烯酸苯并噻唑类似物
标题:设计,合成和生物学评估作为有效的细菌ii型拓扑异构酶抑制剂的α-取代的异二十二烯酸苯并噻唑类似物
摘要:描述和优化抑制细菌dna促旋酶和拓扑异构酶iv的新型苯并噻唑小分子的发现和优化.对dna促旋酶atpase的活性和对金黄色葡萄球菌,粪肠球菌,化脓性链球菌和流感嗜血杆菌的活性证明了抗菌性能.设计用于增强药物相似性的支架的进一步改进包括带有羧酸基团的α-取代基的类似物,从而产生出色的溶解性和非常好的药代动力学特性.
Doi:10.1016/j.Bmcl.2013.10.058

专利信息

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-2004030197-A1
优先权日:2002-07-19
标 题 :Process for the synthesis of phenols from arenes